Email this article EFFICACY OF NARROWBAND ULTRAVIOLET B 311 NM PLUS AN INHIBITOR OF PHOSPHODIESTERASE 4 (PDE4) COMBINED THERAPY IN PATIENTS WITH MODERATE TO SEVERE PLAQUE PSORIASIS
- Authors: Olisova O.Y.1, Grekova E.V1, Svistunova D.A1
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Affiliations:
- Department of Dermatology and Venereology, I. M. Sechenov First Moscow State Medical University (Sechenov University)
- Issue: Vol 22, No 5-6 (2019)
- Pages: 149-155
- Section: Articles
- URL: https://journals.rcsi.science/1560-9588/article/view/42951
- DOI: https://doi.org/10.17816/dv42951
- ID: 42951
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Abstract
Objective. to determine the effectiveness and tolerability of narrowband ultraviolet (UV) B (311 nm) plus an inhibitor of phosphodiesterase 4 (PDE4) combined therapy in patients with moderate to severe plaque psoriasis. Material and methods. the first group consisted of 30 patients (18 women and 12 men) who were treated with UVB 311 nm and inhibitor of phosphodiesterase 4 (PDE4). The second (control) group was treated with UVB 311 nm and methotrexate (n = 30; 15 women and 15 men). The study participants were aged 32 to 67 (43.8 ± 4.34). Results. it was determined greater efficiency (PASI 100 43.3% of patients and PASI 90 46.7%) of the treatment plaque moderate to severe psoriasis patients with UVB 311 nm plus an inhibitor of PDE4 compared to UVB 311 nm plus methotrexate (PASI 100 10% of patients and PASI 90 40%). The treatment was well-tolerated. The side effects in both groups were mild, did not require the cancellation of the prescribed treatment regimen, and were often stopped on their own or with minimal corrective therapy.
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##article.viewOnOriginalSite##About the authors
Olga Yu. Olisova
Department of Dermatology and Venereology, I. M. Sechenov First Moscow State Medical University (Sechenov University)
Email: olisovaolga@mail.ru
MD, PhD, DSc., Head of Department of Dermatology and Venereology, I.M. Sechenov First Moscow State Medical University, Moscow, 119991, Russian Federation Moscow, 119435, Russian Federation
E. V Grekova
Department of Dermatology and Venereology, I. M. Sechenov First Moscow State Medical University (Sechenov University)Moscow, 119435, Russian Federation
D. A Svistunova
Department of Dermatology and Venereology, I. M. Sechenov First Moscow State Medical University (Sechenov University)Moscow, 119435, Russian Federation
References
- Асхаков М.С., Чеботарев В.В. Псориаз современное представление о дерматозе. Медицинский вестник Северного Кавказа. 2017; (2): 225-9.
- Forchhammer S., Ghoreschi K. Update on the treatment of psoriasis and psoriatic arthritis - role of apremilast. Psoriasis: Targets and Therapy. (Auckl). 2015; 5: 117-24.
- AbuHilal M., Walsh S., Shear N. Use of apremilast in combination with other therapies for treatment of chronic plaque psoriasis: a retrospective study. J. Cutan. Med. Surg. 2016; 20(4): 313-6.
- Asawanonda P., Nateetongrungsak Y. Methotrexate plus narrowband UVB phototherapy versus narrowband UVB phototherapy alone in the treatment of plaque-type psoriasis: a randomized, placebo-controlled study. J. Am. Acad. Dermatol. 2006; 54(6): 1013-8.
- Bagel J., Nelson E., Keegan B.R. Apremilast and narrowband ultraviolet B combination therapy for treating moderate-to-severe plaque psoriasis. J. Drugs Dermatol. 2017; 16(10): 957-62.
