APPLICATION OF JANUS-KINASE INHIBITORS IN THE TREATMENT OF ALOPECIA AREATA (LITERATURE REVIEW)


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Abstract

Based on the analysis of data from modern foreign sources current information about using of Janus-kinase inhibitors, in particular, tofacitinid and ruxolitinid, for the treatment of alopecia areata in adults and children, in the presence of a lesion of the scalp and other areas (eyebrows, eyelashes) is shown. The information about the mechanism of action of Janus-kinase inhibitors, the efficacy and safety of their use, possible methods of use, prospects for further research in the treatment of alopecia areata using targeted drugs is presented. The pathogenetic rationale for the possibility of using this group of drugs for treating immune-mediated diseases, for instance, alopecia areata is described.

About the authors

Anfisa A. Lepekhova

Department of skin and venereal diseases of I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: anfisa.lepehova@yandex.ru
MD, PhD, associate professor of the Department of skin and venereal diseases of I.M. Sechenov First Moscow State Medical University (Sechenov University), 119435, Moscow, Russian Federation 119435, Moscow, Russian Federation

L. M Chernyavskaya

Department of skin and venereal diseases of I.M. Sechenov First Moscow State Medical University (Sechenov University)

119435, Moscow, Russian Federation

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