Seborrheic pemphigus associated with viral infection


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Abstract

Association of viral infections with autoimmune diseases is a well-known fact. Herpesvirus infections are often assumed to be involved in the development of autoimmune pemphigus. It is however probable that the virus association with pemphigus is accidental, caused by iatrogenic immunosuppression and/or dysregulation of the host immune response. The authors present a case of seborrheic pemphigus manifestation associated with a chronic infection caused by cytomegalovirus and Epstein-Barr virus. High titers of specific IgG antibodies to protein components of these viruses indicate the persistence of herpesvirus infection and its probable subclinical course with involvement of various organs and tissues. Study of the role of viral infection in the development and course of autoimmune pemphigus considering the antigenic heterogeneity and formation of specific antibodies to the virus protein components is expected to promote the creation of more effective therapeutic protocols and new approaches to the treatment ofpatients suffering from autoimmune pemphigus.

About the authors

Natalia V. Makhneva

M.F. Vladimirsky Moscow Regional Research and Clinical Institute

Email: makhneva@mail.ru
MD, PhD, DSc, prof. 129110, Moscow, Russia

M. G Kartashova

M.F. Vladimirsky Moscow Regional Research and Clinical Institute

кандидат мед. наук 129110, Moscow, Russia

N. I Syuch

P.V. Mandryk Medical Education and Research Clinical Center

доктор мед. наук 107014, Moscow, Russia

V. V Voronova

M.F. Vladimirsky Moscow Regional Research and Clinical Institute

аспирант 129110, Moscow, Russia

V. A Zaidenov

V.I. Shumakov Federal Center of Transplantology and Artificial Organs

кандидат мед. наук 123182, Moscow, Russia

L. V Beletskaya

доктор мед. наук, профессор

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