Modern concepts on the histophysiology of hair follicles


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Abstract

Published data on the regulation of hair growth cycles are reviewed. A hair follicle undergoes cyclic transformations from the resting phase (telogen) to the growth phase (anagen), which is characterized by rapid proliferation of follicular keratinocytes, elongation and thickening of the hair shaft. The regression phase (catagen) leads to involution of the hair follicle. These cyclic changes are associated with rapid remodeling of the epithelial and dermal components, regulated by numerous factors: sex hormones, neutrophils, FGF, TGF, BMP, VEGF, Sonic Hedgehog, SHH, and other signalmolecules.

About the authors

V. L Goryachkina

I.M. Setchenov First Moscow State Medical University

Кафедра гистологии, цитологии и эмбриологии; кандидат биол. наук, доцент 119991, Moscow, Russia

M. Yu Ivanova

I.M. Setchenov First Moscow State Medical University

Email: ivanova_m_y@mail.ru
Кафедра гистологии, цитологии и эмбриологии; кандидат мед. наук, доцент 119991, Moscow, Russia

D. A Tsomartova

I.M. Setchenov First Moscow State Medical University

Email: dtsomartova@mail.ru
Кафедра гистологии, цитологии и эмбриологии; кандидат мед. наук, доцент 119991, Moscow, Russia

N. L Kartashkina

I.M. Setchenov First Moscow State Medical University

Email: knlmma@mail.ru
Кафедра гистологии, цитологии и эмбриологии; кандидат мед. наук, доцент 119991, Moscow, Russia

S. L Kuznetsov

I.M. Setchenov First Moscow State Medical University

Email: vakmedbiol@rambler.ru
Кафедра гистологии, цитологии и эмбриологии; доктор мед. наук, профессор 119991, Moscow, Russia

Konstantin M. Lomonosov

I.M. Setchenov First Moscow State Medical University

Email: lamсlinic@yandex.ru
MD, PhD, DSc, prof. 119991, Moscow, Russia

V. A Zaborova

I.M. Setchenov First Moscow State Medical University

Email: vaz111v@gmail.com
кафедра спортивной медицины и медицинской реабилитации; кандидат мед. наук, доцент 119991, Moscow, Russia

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