Correction of age-associated changes in the skin in women by amino acid cluster


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Abstract

Chronoaging (natural aging) is associated with involutive changes in the skin. Correction of these changes is one of the main tasks of cosmetology and plastic surgery. Use of a functional amino acid cluster (50% glycine, 37% proline, 6% lysine, 7% leucine, and 1% sodium hyaluronate solution) is highly effective. A total of 72 women aged 35-55 years with clinical manifestations of involutive changes in the skin received a course of 4 procedures at 7-10-day intervals. Noninvasive diagnostic methods (laser confocal microscopy, ultrasonic scanning of the skin, videoscanning) showed that intradermal injections of the functional amino acid complex led to improvement of the structural and morphofunctional organization of the epidermis and derma, promoted thickening of the dermal layer, and smoothed out the microrelief. Analysis of GAIS questionnaires showed that the majority of patients were satisfied with the result: 85% women evaluated the result by 2-3 points, which could be interpreted as a “significant improvement” and “improvement”, corresponding to manifest correction of skin aging.

About the authors

S. A Smolyakova

I.M. Setchenov First Moscow State Medical University

Email: dr.smolyakova@gmail.com
Кафедра кожных и венерических болезней; врач-дерматовенеролог, косметолог Moscow, Russia

Olga Yu. Olisova

I.M. Setchenov First Moscow State Medical University

Email: olisovaolga@mail.ru
MD, PhD, DSc, prof. Moscow, Russia

References

  1. Аравийская Е.Р. Изменения кожи в перименопаузе. Принципы современной комплексной коррекции. Клиническая дерматология и венерология. 2007; 2: 97-100.
  2. Анисимов В.Н. Молекулярные и физиологические механизмы старения. М.: Наука; 2003.
  3. Игнатьева Н. Коллаген - основной белок соединительной ткани. Эстетическая медицина. 2005; 3: 246-56.
  4. Фитцпатрик Д.Е. Гериатрическая дерматология. В кн.: Фитцпатрик Д. Е., Эллинг Д.А. Секреты дерматологии. Пер. с англ. М. - СПб.: Бином-Невский диалект; 1999: 436-43.
  5. Lee D.E., Cho K.H. The effects of epidermal keratinocytes and dermal fibroblasts on the formation of cutaneous basement membrane in three dimensional culture systems. Arch. Dermatol. Res. 2005; 296(7): 296-302.
  6. Fisher G.J., Varani J., Voorhees J.J. Looking older: fibroblast collapse and therapeutic Implications. Arch. Dermatol. 2008; 144(5): 666-72. doi: 10.1001/archderm.144.5.666.
  7. Fisher G.J., Voorhees J.J. Molecular mechanisms of retinoid actions in skin. FASEB J. 1996;10(9): 1002-13.
  8. Утц С.Р., Одоевская О.А. Морфофункциональные особенности женской кожи. Вестник дерматологии и венерологии. 1999; 3: 8-13.
  9. Varani J., Warner R.L., Gharaee-Kermani M., Phan S.H., Kang S., Chung J.H. et al. Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. J. Invest. Dermatol. 2000; 114(3): 480-6.
  10. Varani J., Dame M.K., Rittie L., Fligiel S.E., Kang S., Fisher G.J., Voorhees J.J. Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation. Am. J. Pathol. 2006; 168(6): 1861-8.
  11. Тихонова И.В. Исследование регуляции кровотока в микроциркуляционном русле кожи человека в процессе старения: Автореф. дис.. канд. биол. наук. Пущино; 2006.
  12. Смирнова И. Функциональная морфология старения. Успехи геронтологии. 2004; 13: 44-51.
  13. Quan T., Qin Z., Xia W., Shao Y., Voorhees J.J., Fisher G.J. Matrixdegrading metalloproteinases in photoaging. J. Invest. Dermatol. Symp. Proc. 2009; 14(1): 20-4.
  14. Fisher G.J., Kang S., Varani J., Bata-Csorgo Z., Wan Y., Datta S., Voorhees J.J. Mechanism of photoaging and chronological skin aging. Arch. Dermatol. 2002; 138(11): 1462-70.
  15. Румянцева Е.Е., Саромыцкая А.Н., Ковальская М.А. Роль аминокислот в поддержании структурной целостности волокон коллагена: возможности заместительной терапии. Инъекционные методы в косметологии. 2011; 3: 52-63.
  16. Дьяченко Ю.Ю., Румянцева Е.Е. Наиболее эффективные лифтинговые методики в мезотерапии. III Международный форум Валлекс, Москва, 1-3 октября 2011. М.; 2011.
  17. Тимофеев Г.А. Методы аппаратного исследования кожи человека. Косметика и медицина. 2005; 4: 28-36.
  18. Витрук Т.Ю. Особенности изменений клеточно-матриксных взаимоотношений в коже при ее хронологическом и фотоиндуцированном старении: Автореф. дис. канд. мед. наук. Томск; 2008.
  19. Wang F., Garza L.A., Kang S., Varani J., Orringer J.S., Fisher G.J., Voorhees J.J. In vivo stimulation of de novo collagen production caused by cross-linked hyaluronic acid dermal filler injections in photodamaged human skin. Arch. Dermatol. 2007; 143(2): 155-63.
  20. Jenkins G. Molecular mechanisms of skin ageing. Mechanisms of ageing and development. Biol. Ageing. 2002; 123(7): 801-10.
  21. Лащинина Е., Спаравинья А. Препарат JALUPRO в комплексе ухода за стареющей кожей. Инъекционные методы в косметологии. 2010; 2: 76-7.
  22. Pierard G.E. EEMCO guidance for the assessment of dry skin (xerosis) and ichthyosis: evaluation by stratum corneum strippings. Skin Res. Technol. 1996; 2(1): 3-11.
  23. DeLorenci C., Weinberg M., Solish N., Swift A. Multicenter study of the efficacy and safety of subcutaneous non-animal-stabilized hyaluronic acid in aesthetic facial contouring: interim report. Dermatol. Surg. 2006; 32(2): 205-11.
  24. Sorrel J.M., Caplan A.I. Fibroblast geterogeneity more than skin deep. J. Cell Sci. 2004; 117(Pt 5): 667-75.
  25. Sparavigna A., Forte R., Dioguardi F.S. Multicenter study of the evaluation of tolerance and efficacy of a new integrates aminoacidic treatment on the aging face. International Italian Society of Plastic - Aestetic and Oncologic Dermatology. 2007. www.jalupro.com
  26. Sparavigna A. Multicenter clinical and instrumental study for the evaluation of efficacy and tolerance of an intradermal injectable product as a biorevitalizer for the aging face. Institute of clinical research and Bioengineering. May 2007. www.jalupro.com
  27. Chang H.Y., Chi J.T., Dudoit S., Bondre C., van de Rijn M., Botstein D., Brown P.O. Diversity, topographic differentiation, and positional memory in human fibroblasts. Proc. Natl. Acad. Sci. USA. 2002; 99(20): 12877-82.
  28. Marionnet C., Pierrard C., Vioux-Chagnoleau C., Sok J., Asselineau D., Bernerd F. Interactions between fibroblasts and keratinocytes in morphogenesis of dermal epidermal junction in a model of reconstructed skin. J. Invest. Dermatol. 2006; 126(5): 971-9.
  29. Stephens P., Genever P. Non-epithelial oral mucosal progenitor cell populations. Oral. Dis. 2007; 13(1): 1-10.

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