Modern concepts of the epigenetic mechanisms of atopic dermatitis formation


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Abstract

Gene expression in atopic dermatitis was analyzed and the epigenetic profiles (DNA methylation status) of biopsy specimens from normal subjects and patients with atopic dermatitis before therapy were studied by the Illumina microchips in order to detect the key components of the pathological process. The results suggested more rational therapeutic approaches with consideration for the results of individual epigenetic testing.

About the authors

L. N Kayumova

I.M. Setchenov First Moscow Medical University

Email: avestohka2005@inbox.ru
аспирант, кафедра кожных и венерических болезней 119991, Moscow, Russia

- Sami Baker

I.M. Setchenov First Moscow Medical University

аспирант, кафедра кожных и венерических болезней 119991, Moscow, Russia

S. A Bruskin

N.I. Vavilov Institute of Genetics

Email: brouskin@vigg.ru
кандидат биол. наук, заведующий лабораторией функциональной геномики 119333, Moscow, Russia

L. G Garanyan

I.M. Setchenov First Moscow Medical University

клинический ординатор, кафедра кожных и венерических болезней 119991, Moscow, Russia

Nikolay G. Kochergin

I.M. Setchenov First Moscow Medical University

Email: nkocha@yandex.ru
MD, PhD, D.Sc., prof. 119991, Moscow, Russia

O. Yu Olisova

I.M. Setchenov First Moscow Medical University

Email: olisovaolga@mail.ru
заведующая кафедрой, доктор мед. наук, профессор, кафедра кожных и венерических болезней 119991, Moscow, Russia

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