Email this article Invasive capacity and proliferative activity of cutaneous melanoma and the epigenetic factor
- Authors: Aksenenko M.B1, Ruksha T.G.1
-
Affiliations:
- V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
- Issue: Vol 17, No 5 (2014)
- Pages: 4-8
- Section: Articles
- URL: https://journals.rcsi.science/1560-9588/article/view/36881
- DOI: https://doi.org/10.17816/dv36881
- ID: 36881
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Abstract
The invasive capacity and proliferative activity of the tumor are evaluated by immunohistochemical measurement of N-cadherin and Ki-67 expression in patients with cutaneous melanoma with and without BRAF oncogene V600E mutation. The B-Raf is a serine/threonine kinase involved in the Ras-Raf-MEK-MAPK signal pathway. This signal cascade normally regulates the cell proliferation andfunctioning, controlled by growth factors and hormones. The BRAF gene mutation is detected in 40-60% melanomas, predominantly in the tumors located in the closed parts of the body. The expression of N-cadherin is liable to increase in BRAF+ patients, this, in turn, presumably indicating more marked invasive characteristics of tumors in this patient population. The expression of Ki-67 virtually does not differ in patients with different BRAF status (p>0.05), this indicating no differences in the proliferative activity in these patients.
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##article.viewOnOriginalSite##About the authors
M. B Aksenenko
V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
Email: aksenenko_mariya@mail.ru
кандидат мед. наук 660022, Krasnoyarsk, Russia
Tatyana G. Ruksha
V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
Email: tatyana_ruksha@mail.ru
MD, PhD 660022, Krasnoyarsk, Russia
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