Dermatoheliosis: cutaneous epithelial tumor predictor


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Abstract

The incidence of ultraviolet-induced cutaneous tumors is steadily increasing all over the world (in the USA, Europe, Russia). According to the WHO data, about 140 000 melanoma cases and more than 2 000 000 cases with other variants of malignant cutaneous tumors are diagnosed annually, every third case is basal-cell cutaneous cancer. The main carcinogen responsible for the development of cutaneous tumors and provoking early development of photoaging UV spectrum of solar radiation. Penetrating through the epidermis, the A and B spectra rays cause direct and oxidative-stress-mediated damage to cellular DNA. Emergence of cell mutations, stimulation of carcinogenesis initiation and promotion lead to a complex of changes at the epidermal/dermal level, united by the notion “dermatoheliosis” (photoaging). The basic characteristic of dermatoheliosis, in addition to various clinical manifestations, is high risk of pre- and malignant epithelial cutaneous tumors. The most important mechanisms protecting the skin structures from UV exposure are hyperkeratosis and melanogenesis.

About the authors

Elena S. Snarskaya

I.M. Setchenov First Moscow State Medical University

Email: snarskaya-dok@mail.ru
MD, PhD, D.Sc, prof. 119991, Moscow, Russia

S. B Tkachenko

I.M. Setchenov First Moscow State Medical University

доктор мед. наук, профессор, лаборатория по изучению репаративных процессов в коже НИЦ 119991, Moscow, Russia

E. V Kuznetsova

I.M. Setchenov First Moscow State Medical University

Email: kuznetsova-ek@bk.ru
аспирантка, лаборатория по изучению репаративных процессов в коже НИЦ 119991, Moscow, Russia

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