Clinical observation of Muir-Tor-rais's syndrome


Cite item

Full Text

Abstract

Muir-Torrais ’ syndrome in a 60-year-old patient with a history of rectal adenocarcinoma and papillary cancer of the renal pelvis is described. The syndrome included corneal keratoacanthoma, sebaceous gland adenoma, and rectal adenocarcinoma. Keratoacanthoma was cured by peritumor injections of reaferon (interferon-a2b, 1.5 • 10 6 U every other day, 9 injections per course). Rectal cancer, diagnosed at the early stage, was effectively treated by surgery. During the subsequent 2 years the patient developed gastric cancer, which was also treated surgically with good results. The favorable course (without metastases) of visceral cancer in Muir-Torrais’s syndrome and the importance of detecting tumors of the sebaceous glands in patients with keratoacanthoma are emphasized.

About the authors

V. A Molochkov

M.F. Vladimirsky Research and Clinical Institute

Email: derma@monikiweb.ru
Department of Dermato-Venereology and Dermato-Oncology

Zh. S Kuntsevich

M.F. Vladimirsky Research and Clinical Institute

Email: j_s_k@mail.ru
Department of Dermato-Venereology and Dermato-Oncology

S. D Dibirova

M.F. Vladimirsky Research and Clinical Institute

Email: derma@monikiweb.ru
Department of Dermato-Venereology and Dermato-Oncology

Yu. V Molochkova

M.F. Vladimirsky Research and Clinical Institute

Email: derma@monikiweb.ru
Department of Dermato-Venereology and Dermato-Oncology

K. V Kazantseva

M.F. Vladimirsky Research and Clinical Institute

Email: derma@monikiweb.ru
Department of Dermato-Venereology and Dermato-Oncology

References

  1. Молочков В.А., Кунцевич Ж.С., Хлебникова А.Н., Власова М.А., Бочкарева Е.В., Лавров Д.Б. Случай синдрома Мюир-Торре. Российский журнал кожных и венерических болезней. 2011; 5: 31-3.
  2. Rothenberg J., Lambert W.C., Vail J.T.Jr., Nemlick A.S., Schwartz R.A. The Muir-Torre (Torre’s) syndrome: the significance of a solitary sebaceous tumor. J. Am. Acad. Dermatol. 1990; 23 (4, Pt 1): 638-40.
  3. Schwartz R.A. Keratoacanthoma. J. Am. Acad. Dermatol. 1994; 30(1): 1-19.
  4. Schwartz R.A., Torre D.P. J. The Muir-Torre syndrome: a 25-year retrospect. J. Am. Acad. Dermatol. 1995; 33(1): 90-104.
  5. Spraul C.W., Lang G.E., Grossniklaus H.E., Lung G.K. Metastatic adenocarcinoma to the retina in a patient with Muir-Torre syndrome. Am. J. Ophthalmol. 1995; 120(2): 248-50.
  6. Молочков В.А., Молочков А.В. Клиническая дерматоонкология. М.: Cтудия МДВ; 2011.
  7. Cohen P.R., Kohn S.R., Kurzrock R. Association of sebaceous gland tumors and onternal malignancy: the Muir-Torre syndrome. Am. J. Med. 1991; 90(5): 606-13.
  8. Bapat B., Xia L., Madlensky L., Mitri A., Tonin P., Narod S.A., Gallinger S. The genetic basis of Muir-Torre syndrome. Am. J. Hum. Genet. 1996; 59(3): 736-9.
  9. Молочков В.А., Казанцева И.А., Кунцевич Ж.С., Бочкаре ва Е.В. Кератоакантома. Клиника, диагностика, лечение, трансформация в рак. М.: БИНОМ; 2006.
  10. Graells J., Marcoval M., Badell A., Notario J., Fulladosa X. Muir-Torre syndrome in a patient with acquired immunodeficiency syndrome. Br. J. Dermatol. 1996; 135(1): 159-61.
  11. Hartig C., Stieler W., Stadler R. Muir-Torre syndrome. Diagnostic criteria and review of the literature. Hautarzt. 1995; 46(2): 107-13.
  12. Matthews J.J., Roberts R., O’Reilly D.A., Schick S., Kingsnorth A.N. Muir-Torre syndrome: a case for surveillance of the ampulla of Vater. Dig. Surg. 2002; 19(1): 65-6.

Copyright (c) 2014 Eco-Vector


 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies