Amylolytic nodular melanoma of the shin skin
- Authors: Snarskaya E.S1, Avetisyan K.M1, Andryukhina V.V2
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Affiliations:
- I.M. Setchenov First Moscow State Medical University
- M.F. Vladimirsky Moscow Regional Research and Clinical Institute
- Issue: Vol 17, No 2 (2014)
- Pages: 4-7
- Section: Articles
- URL: https://journals.rcsi.science/1560-9588/article/view/36828
- DOI: https://doi.org/10.17816/dv36828
- ID: 36828
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Abstract
According to published data, the incidence of cutaneous melanoma is the highest after 50 years of age; the mortality is almost 80%, because of high metastatic potential of the tumor and low level of diagnosis of amylolytic forms of the disease. Melanoma is a familial disease in 5-12% cases; some data indicate an autosomal dominant inheriting with incomplete penetration or more intricate mechanisms of melanoma inheriting. Mutations in CD-KN2A and CDK genes are responsible for 20-25% high risk cases in families. According to modern concepts, the mechanisms of accumulated genetic mutations modulate significantly the signal route cascades and stimulate the production of adhesion molecules E- and N-cadherins, a- and b-integrin, and b-catenin, which are assumed to be the main molecular processes in the pathogenesis of melanoma. A rare clinical case is presented: afemale patient with positive oncological family history developed amylolytic nodular melanoma on the skin of the shin.
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##article.viewOnOriginalSite##About the authors
E. S Snarskaya
I.M. Setchenov First Moscow State Medical University
Email: snarskaya-dok@mail.ru
доктор мед. наук, профессор; Кафедра кожных и венерических болезней
K. M Avetisyan
I.M. Setchenov First Moscow State Medical University
Email: avetisyan.ka@bk.ru
клинический ординатор; Кафедра кожных и венерических болезней
V. V Andryukhina
M.F. Vladimirsky Moscow Regional Research and Clinical Instituteкандидат мед. наук; Отделение челюстно-лицевой хирургии
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