CHRONIC URTICARIA AS AN AUTOIMMUNE DISEASE


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Abstract

The authors of this review of literature discuss the pathogenesis of autoimmune urticaria and the history of its distinguishing as a nosological entity. These data on autoimmune urticaria will be useful for specialists and will promote optimization of its diagnosis and therapy. Some autoimmune diseases can manifest by symptoms of chronic urticaria; on the other hand, urticaria is autoimmune in 30—40% cases. In addition, it is assumed that the disease is associated with the presence of autoantibodies — anti-FcεRI and (rarely) anti-IgE. It is essential to differentiate autoimmune urticaria from other disease forms by intradermal test with autoimmune serum and in vitro studies. It is characterized by a more severe prolonged course and resistance to antihistaminic therapy. In many cases the diagnosis of autoimmune urticaria allows dscontinuing further tests, aimed at detection of the disease cause.

About the authors

P. V Kolkhir

I.M. Setchenov First Moscow State Medical University

Email: arthate@yandex.ru
кандидат мед. наук, старший научный сотрудник; Научно-исследовательский отдел иммунозависимых дерматозов (зав. — проф. Н.Г. Кочергин) Научно-исследовательского центра

O. Yu Olisova

I.M. Setchenov First Moscow State Medical University

доктор мед. наук, профессор; кафедра кожных и венерических болезней

N. G Kochergin

I.M. Setchenov First Moscow State Medical University

доктор мед. наук, профессор

D. V Ignatyev

I.M. Setchenov First Moscow State Medical University

врач; кожно-венерологическое отделение клиники кожных и венерических болезней им. В.А. Рахманова

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