ANDROGENIC ALOPECIA: PATHOGENETIC MECHANISMS AND THERAPEUTIC APPROACHES


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Androgenic alopecia remains one of the most common variants of hair loss. Changes in androgen metabolism and genetic liability underlie this process. Androgenic alopecia develops under conditions of high serum levels of free testosterone and the so-called weak androgens in the presence of high levels of androgen receptors and 5a-reductase. As for the genetics of the process, a relationship between androgenic hair loss and chromosome X locus 20p11 has been described. The disease is rather stubborn. Finasteride and minoxidil remain the most effective therapy. The first results of therapy with botuloxin A and platelet-rich plasma have been published. The available treatment is effective in just 10% patients. This necessitates search for new approaches to solution of the problem.

作者简介

O. Olisova

I.M.Setchenov First Moscow State Medical University

доктор мед. наук, профессор

N. Kochergin

I.M.Setchenov First Moscow State Medical University

доктор мед. наук, профессор

E. Vertieva

I.M.Setchenov First Moscow State Medical University

Email: ivertieva@gmail.com
врач, кандидат мед. наук

参考

  1. Trueb R.M. Molecular mechanism of androgenetic alopecia. Exp. Gerontol. 2002; 37(8-9): 981-90.
  2. Кардашова Д.З., Василенко И.А., Ли В.А., Карасев Е.А. Комплексный подход - основа эффективного лечения алопеции. Экспериментальная и клиническая дерматокосметология. 2012; 1: 58-63.
  3. Rendal V.A. Molecular basis of androgenetic alopecia. Aging Hair. 2010; 9: 9-24.
  4. Баткаев Э.А., Галлямова Ю.А., Хассан Аль-Хадж Халед. Диффузная алопеция. Методическое пособие. М.; 2010: 1-32.
  5. Вольф К., Лоуэлл А. Голдсмит, Кац И. Дерматология Фицпатрика в клинической практике. Т. 1. М.: Бином; 2012: 807-15.
  6. Reynolds A.J., Jahoda C.A. Cultured dermal papilla cells induce follicle formation and hair growth by transdifferentiation of an adult epidermis. Development. 1992; 115(2): 587-93.
  7. Cotsarelis G. Epithelial stem cells: a folliculocentic view. Journal of Investigative Dermatology. 2006; 126(7): 1459-68.
  8. Костиленко Ю.П., Тихонова О.А. Особенности строения кожи волосистого отдела головы мужчин при андрогенной алопеции. Морфология. 2009; ІІІ(3): 60-5.
  9. Stenn K.S., Paus R. Controls of hair follicle cycling. Physiol. Rev. 2001; 81(1): 450-94.
  10. Rushton D.H., Ramsay I.D., Norris M.J., Gilkes J. Natural progression of male pattern baldness in young men. Clin. Exp. Dermatol. 1991; 16(3): 188-92.
  11. McPhaul M.J. Molecular defects of the androgen receptor. Recent. Prog. Horm. Res. 2002; 57: 181-94.
  12. Szafran A.T., Hartig S., Sun H., Uray I.P., Szwarc M., Shen Y., et al. Androgen receptor mutations associated with androgen insensitivity syndrome: a high content analysis approach leading to personalized medicine. PLoS One. 2009; 4(12): e8179. doi: 10.1371/journal.pone.0008179.
  13. Sawaya M.E., Shapiro J. Androgenetic alopecia. New approved and unapproved treatments. Clin. Dermatol. J. 2000; 18(1):47-61.
  14. Phillipou G., Kirk J. Significance of steroid measurements in male pattern alopecia. Clin. Exp. Dermatol. 1981; 6(1): 53-6.
  15. Ellis J.A., Harrap S.B. The genetics of androgenetic alopecia. Clin. Dermatol. 2001; 19(2): 149-54.
  16. Ellis J.A., Stebbing M., Harrap S.B. Genetic analysis of male pattern baldness and the 5alpha-reductase genes. J. Invest. Dermatol. 1998; 110(6): 849-53.
  17. Ellis J.A., Stebbing M., Harrap S.B. Polymorphism of the androgen receptor gene is associated with male pattern baldness. J. Invest. Dermatol. 2001; 116(3): 452-5.
  18. Brockschmidt F., Heilmann S., Hillmer A., Nothen M. Androgenetic alopecia: identification of genetic susceptibility factors and first steps towards development of a predictive test. Int. J. Trichol. 2011; 3(Suppl.1): S1.
  19. Make Y.F., Michelet J.F., Billoni N., Jarrousse F., Buan B., Com-mo S., et al. Androgenetic alopecia and microinflammation. Int. J. Dermatol. 2000; 39(8): 576-84.
  20. Eschiletti M.A., Goldim J.R., Bakos L., Gross J.L. Effect of the combination of cyproterone acetate and conjugated estrogens on hirsutism, alopecia and acne. AMB Rev. Assoc. Med. Bras. 1986; 32(3-4): 61-4.
  21. Adamopoulos D.A., Karamertzanis M., Nicopoulou S., Gregoriou A. Beneficial effect of spironolactone on androgenic alopecia. Clin. Endocrinol. (Oxf). 1997; 47(6): 759-60.
  22. McClellan K.J., Markham A. Finasteride: a review of its use in male pattern hair loss. Drugs. 1999; 57(1): 111-26.
  23. Kaufman K.D., Olsen E.A., Whiting D., Savin R., DeVillez R., Bergfeld W., et al. Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male Pattern Hair Loss Study Group. J. Am. Acad. Dermatol. 1998; 39(4, Pt 1): 578-89.
  24. Olsen E.A., Hordinsky M., Whiting D., Stough D., Hobbs S., Ellis M.L., et al. ; Dutasteride Alopecia Research Team. The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride. J. Am. Acad. Dermatol. 2006; 55(6): 1014-23.
  25. Matias J.R., Orentreich N., Malloy V., De Feo C.P. 3rd, Matias L. The lack of effect of 11 alpha-hydroxyprogesterone on the flankorgan and ear sebaceous glands of adult male Syrian golden hamsters. Arch. Dermatol. Res. 1984; 276(5): 346-8.
  26. Orfanos C.E., Vogels L. Local therapy of androgenetic alopecia with 17 alpha-estradiol. A controlled, randomized double-blind study. Dermatologica. 1980; 161(2): 124-32.
  27. Messenger A.G., Rundegren J. Minoxidil: mechanisms of action on hair growth. Br. J. Dermatol. 2004; 150(2): 186-94
  28. Гаджигороева А.Г. Миноксидил в лечении алопеции. Вестник дерматологии и венерологии. 2006; 5: 87-93.
  29. Freund B.J., Schwartz M. Treatment of male pattern baldness with botulinum toxin: a pilot study. Plast. Reconstr. Surg. 2010; 126(5):246e-248e. doi: 10.1097/PRS.0b013e3181ef816d
  30. Rinaldi F., Sorbellini E., Coscera T. The role of plateler rich plasma to control anagen phase: evaluation in vitro and in vivo in hair transplant and hair treatment. Int. J. Trichol. 2011; 3(1): 14-15.

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