GENE METHYLATION IN CD3+ CELLS IN PSORIASIS


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Abstract

Gene methylation level in CD3+ cells of psoriasis patients in comparison with that in normal subjects was analyzed using Illumina microchips. Differentially methylated locuses were detected in CD3+ cells of psoriasis patients and normal subjects. FRK, JAK1, AKAP7, DYRK1A, PRKCA, RPS6KA2 kinase genes were detected in the most methylated locuses in CD3+ cells of psoriasis patients. The clear-cut separation of the samples into two groups suggested that the level of the studied genes methylation in CD3+ cells can serve for predicting liability to psoriasis and presumably for diagnosis of its early stages.

About the authors

V. V Sobolev

ФГБУН Институт общей генетики им. Н.И. Вавилова РАН

Email: sobolew_vl@mail.ru
канд. биол. наук

E. V Denisova

ФГБУН Центр теоретических проблем физико-химической фармакологии РАН

врач-дерматолог

A. G Soboleva

ФГБУН Институт общей генетики им. Н.И. Вавилова РАН

канд. биол. наук

I. M Korsunskaya

Городская клиническая больница № 14 им. В.Г. Короленко; ГБОУ ВПО Первый МГМУ им. И.М. Сеченова Минздрава России

д-р мед. наук, профессор

E. V Chekalin

ФГБУН Институт общей генетики им. Н.И. Вавилова РАН

студент

A. D Zolotarenko

ФГБУН Институт общей генетики им. Н.И. Вавилова РАН

аспирант

S. A Bruskin

ФГБУН Институт общей генетики им. Н.И. Вавилова РАН

канд. биол. наук

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