Toll receptor 4 and 9 gene polymorphisms in patients with psoriasis


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Abstract

The prevalence of TLR4 (C6898A) and TLR9 (A2848G) gene polymorphisms and their associations with case history and clinical picture were studied in 425 patients of both genders, aged 18-80 years, with advanced stage of psoriasis vulgaris. Associations of TLR4 6898C/A mutant allele A with the guttat-type psoriasis, presence of psoriasis in the patient’s close relatives, presence of concomitant infectious or parasitic diseases, low dermatological quality of life index, and frequent relapses of the pathological process were detected. The TLR9 (A2848G) mutant allele G was associated with liability to exudation of psoriatic elements, inefficiency of therapy, high PASI score before therapy and its lesser changes over the course of treatment.

About the authors

V. A Okhlopkov

Omsk State Medical Academy

Email: ochlopkov@omsk-osma.ru
доктор мед. наук, профессор

A. I Novikov

Omsk State Medical Academy

доктор мед. наук, профессор

A. V Kononov

Omsk State Medical Academy

доктор мед. наук, профессор

E. G Pomorgailo

Omsk State Medical Academy

кандидат биол. наук, доцент

E. A Petrova

Omsk State Medical Academy

аспирант

O. V Pravdina

Omsk State Medical Academy

кандидат мед. наук, доцент

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