The role of immune cells and cytokines in the development of psoriasis


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Abstract

The role of the immune system cells and cytokines they produce in the pathogenesis of an autoimmune disease - psoriasis - is discussed. The immune cells infiltrating the skin of psoriatic patients and keratinocytes - components of congenital immunity and inflammatory process - are characterized. The role of proinflammatory cytokines TNFα, IFNγ, IL-17, IL-22, and IL-20 in initiation and development of psoriatic inflammation is shown.

About the authors

B. V Pinegin

State Research Center - Institute of Immunology

O. L Ivanov

I.M.Setchenov First Moscow State Medical University

V. B Pinegin

I.M.Setchenov First Moscow State Medical University

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