CD45 IN CUTANEOUS MELANOMA CELLS AS A MANIFESTATION OF TUMOR ATYPIA


Cite item

Full Text

Abstract

The expression of CD45 (hemopoietic cell marker) in cutaneous melanoma cells was studied in 96 patients (40 men and 56 women). The expression was detected in 17.5% patients, mainly with Clark’s tumor invasion levels IV and V and Breslow’s thickness of the tumor 3.7±1.09 mm. Data on the relationship between this marker’s expression and clinical morphological characteristics of the disease are presented. The differential diagnosis of cutaneous melanoma is discussed.

About the authors

M. B Aksenenko

V.F.Voino-Yasenetsky Krasnoyarsk State Medical University

Email: aksenenko_mariya@mail.ru
Кафедра патологической физиологии с курсом клинической патофизиологии им. проф. В. В. Иванова ассистент

L. A Shestakova

V.F.Voino-Yasenetsky Krasnoyarsk State Medical University

Email: patholog-lan@yandex.ru
кандидат мед. наук, доцент

T. G Ruksha

V.F.Voino-Yasenetsky Krasnoyarsk State Medical University

Email: tatyana_ruksha@mail.ru
Кафедра патологической физиологии с курсом клинической патофизиологии им. проф. В. В. Иванова доктор мед. наук

References

  1. Stoeter D., de Liguori Carino N., Marshall E., Poston G.J., Wu A. Extensive necrosis of visceral melanoma metastases after immunotherapy. World J. Surg. Oncol. 2008; 6: 30. doi: 10.1186/14777819-6-30.
  2. Bachmann I.M., Ladstein R.G., Straume O., Naumov G.N., Akslen L.A. Tumor necrosis is associated with increased alpha-v beta-3 integrin expression and poor prognosis in nodular cutaneous melanomas. BMC Cancer. 2008; 8: 362. doi: 10.1186/1471-2407-8-362.
  3. Judkins A.R., Roberts S.A., Livolsi V.A. Utility of immunohistochemistry in the evaluation of necrotic thyroid tumors. Hum. Pathol. 1999; 30(11): 1373-6.
  4. Chen N., Gong J., Chen X., Xu M., Huang Y., Wang L., et al. Cytokeratin expression in malignant melanoma: potential application of in-situ hybridization analysis of mRNA. Melanoma Res. 2009; 19(2): 87-93.
  5. Aisner D.L., Maker A., Rosenberg S.A., Berman D.M. Loss of S-100 antigenicity in metastatic melanoma. Hum. Pathol. 2005; 36(9): 1016-9.
  6. Saleh F.H., Crotty K.A., Hersey P., Menzies S. W., Rahman W. Autonomous histopathological regression of primary tumors associated with specific immune responses to cancer antigens. J. Pathol. 2003; 200(3): 383-95.
  7. Nonaka D., Laser J., Tucker R., Melamed J. Immunohistochemical evaluation of necrotic malignant melanomas. Am. J. Clin. Pathol. 2007; 127(5): 787-91.
  8. Taetle R., Ostergaard H., Smedsrud M., Trowbridge I. Regulation of CD45 expression in human leukemia cells. Leukemia. 1991; 5(4): 309-14.
  9. Judkins A.R., Montone K.T., Livolsi V.A., van de Rijn M. Sensitivity and specificity of antibodies on necrotic tumor tissue. Am. J. Clin. Pathol. 1998; 110(5): 641-6.

Copyright (c) 2013 Eco-Vector


 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies