DIFFERENT APPROACHES TO CLONAL NATURE EVALUATION IN T-CELLULAR SKIN LYMPHOMA


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Abstract

The clonal nature of lymphoid cells was evaluated in skin biopsy and peripheral blood specimens from patients with suspected T-cellular skin lymphoma and with large plaque parapsoriasis transforming into mycosis fungoides.

About the authors

V. A Molochkov

ГУ МОНИКИ им. М.Ф. Владимирского

д-р мед. наук, проф.

Yu. V Sidorova

ГБОУ Гематологический научный центр Минздрава России

канд. мед. наук, науч. сотр.

G. V Menshchikova

ГУ МОНИКИ им. М.Ф. Владимирского

канд. мед. наук, ассистент

A. A Groznova

ГБОУ ВПО Первый МГМУ им. И.М. Сеченова Минздрава России

Email: anna_groznova@list.ru
аспирант

A. V Fedorovskaya

ГУ МОНИКИ им. М.В. Владимирского

аспирант

I. V Yefimovich

ГБОУ ВПО Первый МГМУ им. И.М. Сеченова Минздрава России

Email: iraefimov_115@rambler.ru
аспирант

References

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  2. Dippel E., Assaf C., Hummel M., Schrag H.J., Stein H., Goerdt S., Orfanos C.E. Clonal T-cell receptor gamma-chain gene rearrangement by PCR-based GeneScan analysis in advanced cutaneous T-cell lymphoma: a critical evaluation. J. Pathol. 1999; 188(2): 146—54.
  3. Klemke C.D., Dippel E., Dembinski A., Pönitz N., Assaf C., Hummel M., et al. Clonal T cell receptor gamma-chain gene rearrangement by PCR-based GeneScan analysis in the skin and blood of patients with parapsoriasis and early-stage mycosis fungoides. J. Pathol. 2002; 197(3): 348—54.
  4. Callan M.F., Steven N., Krausa P., Wilson J.D., Moss P.A., Gillespie G.M., et al. Large clonal expansions of CD8+ T cells in acute infectious mononucleosis. Natl. Med. 1996; 2(8): 906—11.
  5. Beylot-Barry M., Sibaud V., Thiebaut R., Vergier B., Beylot C., Delaunay M., et al. Evidence that an identical T cell clone in skin and peripheral blood lymphocytes is an independent prognostic factor in primary cutaneous T cell lymphomas. J. Invest. Dermatol. 2001; 117(4): 920—6.
  6. Kandolf Sekulović L., Cikota B., Stojadinović O., Basanović J., Skiljević D., Medenica L., et al. TCRγ gene rearrangement analysis in skin samples and peripheral blood of mycosis fungoides patients. Acta Dermatovenerol. Alp. Panonica Adriat. 2007; 16(4): 149—55.
  7. Posnett D., Sinha R., Kabak S., Russo C. Clonal populations of T-cells in normal elderly humans. J. Exp. Med. 1994; 179(2): 609—18.

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