Clinical and microbiological comparisons in whooping cough in children under modern conditions


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Abstract

Comparative researches have been performing since 1990th years, and were devoted to the study of the interrelationship ofserotype landscape of circulating B.pertussis strains with the severity of clinical course of whooping cough. The researches performed in the 2000th years, showed that in patients with identified strains of B.pertussis serotype 1.0.3, the proportion of children with heavy forms of an illness, in comparison with the 1990thyears considerably increased, reaching 43,2±5,0%, against 18,6±3,6. The analysis of the dependence of clinical picture manifestations of whooping cough from the genotypes of B.pertussis has been performed in 83 patients, among them children at the age up to 1 year (77,1±4,6% ofpatients) prevailed. Genotyping of strains of B.pertussis was carried out with the help of two schemes of multilocus antigen sequence typing (MAST1 and MAST2). As a result of the study of the influence of genotypic properties of B.pertussis strains on clinical manifestations of an infection the most severe course of disease was established to be caused by strains of B.pertussis of genotypes 932 MAST1, 319 MAST2 and 329 MAST2. In work there is presented the careful analysis of symptomatology of the prodromal period and the spasmodic cough, performed in 2 groups of children with the severe and moderate form ofwhooping cough. In whooping cough caused by B.pertussis strains of genotypes 932 MAST1, 319 MAST2 and 329 MAST2, there are most pronounced symptoms determining the severity ofthe course of infection.

About the authors

O. P Popova

Moscow Scientific Research Institute of Epidemiology and Microbiology named after G.N. Gabrichevsky of the Federal Service for the Oversight of Consumer Protection and Welfare

Email: doctorpopova@yandexl.ru
канд. мед. наук, ст. науч. сотр. клинического отдела 10, Ul. Admirala Makarova, Moscow, Russian Federation, 125212

O. Yu Borisova

Moscow Scientific Research Institute of Epidemiology and Microbiology named after G.N. Gabrichevsky of the Federal Service for the Oversight of Consumer Protection and Welfare

Email: olgborisova@mail.ru
доктор мед. наук, руководитель лаб. диагностики дифтерийной и коклюшной инфекций 10, Ul. Admirala Makarova, Moscow, Russian Federation, 125212

M. S Petrova

Moscow Scientific Research Institute of Epidemiology and Microbiology named after G.N. Gabrichevsky of the Federal Service for the Oversight of Consumer Protection and Welfare

канд. мед. наук, вед. науч. сотр. клинического отдела 10, Ul. Admirala Makarova, Moscow, Russian Federation, 125212

N. M Gracheva

Moscow Scientific Research Institute of Epidemiology and Microbiology named after G.N. Gabrichevsky of the Federal Service for the Oversight of Consumer Protection and Welfare

доктор мед. наук, проф., руководитель клинического отдела 10, Ul. Admirala Makarova, Moscow, Russian Federation, 125212

E. N Abramova

ГКУЗ ИКБ № 1 ДЗМ Москвы

зав. отделением № 2

A. S Pimenova

Moscow Scientific Research Institute of Epidemiology and Microbiology named after G.N. Gabrichevsky of the Federal Service for the Oversight of Consumer Protection and Welfare

мл. науч. сотр. лаб. диагностики дифтерийной и коклюшной инфекций 10, Ul. Admirala Makarova, Moscow, Russian Federation, 125212

N. T Gadua

Moscow Scientific Research Institute of Epidemiology and Microbiology named after G.N. Gabrichevsky of the Federal Service for the Oversight of Consumer Protection and Welfare

канд. мед. наук, ст. науч. сотр. лаб. диагностики дифтерийной и коклюшной инфекций 10, Ul. Admirala Makarova, Moscow, Russian Federation, 125212

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