Features of the immune response in early period of ixodid tick-borne borreliosis
- Authors: Samoylov K.V.1, Koval D.P.1, Ilyinskikh E.N.1, Filatova E.N.1
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Affiliations:
- Siberian State Medical University
- Issue: Vol 28, No 5 (2023)
- Pages: 319-330
- Section: REVIEW ARTICLES
- URL: https://journals.rcsi.science/1560-9529/article/view/148249
- DOI: https://doi.org/10.17816/EID532724
- ID: 148249
Cite item
Abstract
Lyme borreliosis is a group of transmissible infectious diseases that are similar in etiology, but diverse in clinical manifestations. The development of Lyme disease symptoms is due not only to the activity of the pathogen itself, but also to the result of its interaction with immune system of macroorganism. The first line of defense, represented by a variety of cellular and humoral components of innate immunity, is most rapidly involved in immune response, and it is it that seeks to limit dissemination of the causative agent from the initial site of infection. However, a wide range of protective surface proteins of Borrelia and a number of other structures aimed at avoiding immune mechanisms prevent the destruction of the pathogen. Not the last place in this dynamic process is occupied by ixodid ticks themselves, since the secret of their salivary glands has an inhibitory effect on a number of cells and complement system. In parallel with innate immunity, adaptive immune response factors are activated, serving as a second line of defense. The synthesis of specific antibodies in the early period of Lyme disease has its own ambiguous features, but this does not exclude their importance in fight against borreliosis infection. To date, the issues of interaction with dendritic cells and cytotoxic T-lymphocytes remain less studied. Research of all aspects, including little-studied ones, is extremely important for both practical healthcare and fundamental medicine.
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##article.viewOnOriginalSite##About the authors
Kirill V. Samoylov
Siberian State Medical University
Email: samoilov.krl@gmail.com
ORCID iD: 0000-0002-8477-8551
SPIN-code: 4710-0894
Scopus Author ID: 58103184700
ResearcherId: HGC-9557-2022
research laboratory assistant of the Department of Infectious Diseases and Epidemiology
Russian Federation, 2 Moskovsky trakt, 634050 TomskDaniil P. Koval
Siberian State Medical University
Email: daniil.vova555@gmail.com
ORCID iD: 0000-0001-9056-9986
6th year student
Russian Federation, 2 Moskovsky trakt, 634050 TomskEkaterina N. Ilyinskikh
Siberian State Medical University
Email: infconf2009@mail.ru
ORCID iD: 0000-0001-7646-6905
SPIN-code: 5245-5958
Scopus Author ID: 6602611268
MD, Dr. Sci. (Med.), Associate Professor
Russian Federation, 2 Moskovsky trakt, 634050 TomskEvgenia N. Filatova
Siberian State Medical University
Author for correspondence.
Email: synamber@mail.ru
ORCID iD: 0000-0001-9951-8632
SPIN-code: 8094-3417
MD
Russian Federation, 2 Moskovsky trakt, 634050 TomskReferences
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