The combined course of COVID-19 and influenza: clinical presentation, diagnosis, treatment

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Abstract

The new coronavirus infection severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the natural epidemic rise of respiratory infections can occur in combination with them. This report aimed to answer the question that arises regarding features of clinical and laboratory diagnostic characteristics of mixed infections. A group of patients was analyzed with combined course of acute coronavirus infection SARS-CoV-2 and influenza using clinical and laboratory instrumental data. Attention is drawn to the fact that combined course of these nosologies, characterized by a significant decrease in blood oxygen saturation with atmospheric air breathing and moderately pronounced changes of the chest organs according to computed tomography results goes together with a moderate course of the disease. Absolute lymphopenia and high C-reactive protein and fibrinogen levels may be specific markers that confirm viral etiology of this disease. At the same time, high titer of antibodies to SARS-CoV-2 did not always correspond to the full elimination of coronavirus from the body in patients with mixed infection.

About the authors

Viktoriya B. Poluektova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: viktoriya211@mail.ru
ORCID iD: 0000-0002-5053-0312
SPIN-code: 7290-8377

PhD, docent

Russian Federation, Moscow

Elena Yu. Burdova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: ellenburdov@gmail.com
ORCID iD: 0000-0003-0521-4502
SPIN-code: 8451-5845
Russian Federation, Moscow

Anastasia P. Filatova

Research Institute of Emergency Medicine named after N.V. Sklifosovsky

Email: sklif@zdrav.mos.ru
ORCID iD: 0000-0002-1874-9103
SPIN-code: 9065-4087
Russian Federation, Moscow

Elena A. Ladygina

Research Institute of Emergency Medicine named after N.V. Sklifosovsky

Email: sklif@zdrav.mos.ru
ORCID iD: 0000-0001-7343-0667
SPIN-code: 5097-5585
Russian Federation, Moscow

Elizaveta P. Litvinova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: infection_mma@mail.ru
ORCID iD: 0000-0002-5185-0748
Russian Federation, Moscow

Valeri A. Malov

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: infection_mma@mail.ru
ORCID iD: 0000-0002-6157-1654
SPIN-code: 4790-8986

MD, PhD, Professor

Russian Federation, Moscow

Konstantin A. Popugaev

Research Institute of Emergency Medicine named after N.V. Sklifosovsky

Email: sklif@zdrav.mos.ru
ORCID iD: 0000-0003-1945-323X
SPIN-code: 4255-4720

MD, PhD

Russian Federation, Moscow

Elena V. Volchkova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: infection_mma@mail.ru
ORCID iD: 0000-0003-4581-4510
SPIN-code: 3342-4681

MD, PhD, Professor

Russian Federation, Moscow

Sergey S. Petrikov

Research Institute of Emergency Medicine named after N.V. Sklifosovsky

Email: sklif@zdrav.mos.ru
ORCID iD: 0000-0003-3292-8789

MD, PhD, Professor, corresponding member of RAS

Russian Federation, Moscow

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