Humoral antiendotoxic immunity in some infectious diseases of viral and bacterial etiology

In the article there are presented the data of own investigations of changes of antiendotoxic humoral immunity in some infections of bacterial and viral origin - intestinal infections (rotaviral infection, localized forms of salmonellosis, gastroenteritis caused by opportunistic flora) and influenza A. The levels of antibodies to the lipopolysaccharide of Escherichia coli K235 (Sigma Chem. Co., USA) were determined in the serum of 81 patients with acute intestinal moderate infections and in the serum of 62 patients with influenza A /H1N1/California/09/ in various periods of the disease with the use of ELISA method. Studied immunoglobulin M was revealed to rise significantly in diseases of viral and bacterial etiology. More pronounced evidence of such changes of humoral antiendotoxic immunity was observed in acute infectious pathology proceeding with the involvement of the intestine. Obtained by ourselves data may attest to the stimulation of antiendotoxic immunity in the initial period of influenza and compensateness for this process in uncomplicated forms of the disease. The pronounced change in indices of humoral antiendotoxic immunity in cases of bacterial, viral-bacterial disease usually indicated to a more severe or complicated form of the disease. The performed study emphasizes the important role of various viral and bacterial associations and the ability of these associations to the system rather than the local pathogenetic impact on the human organism, in particular on the system of antiendotoxic immunity.

antiendotoxic immunity, intestinal infections