Clinical and laboratory characteristics of influenza in pregnant women in the epidemiological season of 2013-2014


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Abstract

By force of hormonal and physiological changes occurring in the body throughout pregnancy, in the case of the flu, pregnant women are at greater risk of developing complications. In this regard, the study of clinical and pathogenetic features of influenza in pregnant women deserves special attention. So, on the basis of epidemiological data over the past few decades, WHO experts have included pregnant women in groups at risk of severe (complicated) course of the flu. The flu for a pregnant female is a dangerous infection, representing a real threat to the health of the expectant mother and her child. The clinical picture of influenza in pregnant women can vary significantly, and severe complications combine with the development of a pathology of pregnancy, which ultimately exacerbates the condition as well an expectant mother as the fetus. For the study both of the character of the clinical course of influenza in pregnant women and the mechanism of the immunosuppressive state FGBU "Influenza Research Institute" performed a simple multi-center comparative study on the base of the infectious-disease units of the GBOU "NGMU" and the Medical University "KrasGMU named after. prof. V.F. Voyno-Yasenetsky" of the Ministry of Health of the Russian Federation. The obtained results allowed to reveal some clinical and immunological features of the course of influenza in pregnant women: at the peak of the disease there was noted a significant inhibition of induced production of IFN-γ.

About the authors

Ella G. Deeva

Research Institute of Influenza

Email: klinika@influenza.spb.ru
канд. мед. наук, глав. врач специализированной клиники вирусных инфекций 15/17, Professora Popova str. Saint Petersburg, Saint-Petersburg, Russian Federation, 197376

T. V Sologub

Research Institute of Influenza

Email: sologub@influenza.spb.ru
доктор мед. наук, проф. заместитель директора по научной и клинической работе 15/17, Professora Popova str. Saint Petersburg, Saint-Petersburg, Russian Federation, 197376

E. P Tikhonova

Krasnoyarsk State Medical University named after professor V.F. Voyno-Yasenetsky

Email: tihonovaep@mail.ru
доктор мед. наук, проф., зав. каф. инфекционных болезней и эпидемиологии с курсом ПО 1, Partizana Zheleznyaka Str., Krasnoyarsk, Russian Federation, 660022

E. I Krasnova

Novosibirsk State Medical University

Email: krasnova-inf@rambler.ru
доктор мед. наук, проф., зав. каф. инфекционных болезней 52, Krasny Prospect, Novosibirsk, Russian Federation, 630091

N. I Konovalova

Research Institute of Influenza

канд. биол. наук, сотр. лаб. эволюционной изменчивости вирусов гриппа 15/17, Professora Popova str. Saint Petersburg, Saint-Petersburg, Russian Federation, 197376

V. V Zarubaev

Research Institute of Influenza

Email: vladimir.zarubaev@influenza.spb.ru
канд. биол. наук, зав. группой по тестированию специфической активности противовирусных соединений 15/17, Professora Popova str. Saint Petersburg, Saint-Petersburg, Russian Federation, 197376

M. Yu Eropkin

Research Institute of Influenza

Email: mikhail.eropkin@influenza.spb.ru
доктор биол. наук, зав. лаб. эволюционной изменчивости вирусов гриппа 15/17, Professora Popova str. Saint Petersburg, Saint-Petersburg, Russian Federation, 197376

V. V Tsvetkov

Research Institute of Influenza

Email: suppcolor@gmail.com
аспирант, научный сотрудник 15/17, Professora Popova str. Saint Petersburg, Saint-Petersburg, Russian Federation, 197376

G. S Golobokov

Research Institute of Influenza

Email: llama228@yandex.ru
науч. сотр. 15/17, Professora Popova str. Saint Petersburg, Saint-Petersburg, Russian Federation, 197376

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