The possibility of the use of interferon-gamma in Influenza infection


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Abstract

Interferon-gamma (IFN-y) is a pleiotropic lymphokine that have multiple effects on the growth and differentiation of various types of cells associated with innate immunity. IFN-y induces differentiation ofmyeloid cells, stimulates the expression of major histocompatibility complex (MHC) class II and class I antigens, it is a potent activator of macrophages which destroy antigenic molecules penetrating the cell. IFN-y is widely used for the treatment of infectious diseases, cancer, autoimmune and allergic diseases. Studies conducted in Research Institute ofInfluenza indicate that drugs IFN-y can be successfully usedfor prevention of influenza and acute respiratory infection (ARI) during the rise of incidence, as well as for the treatment - the first few days/ hours of the onset. The concomitant use of drugs as IFN-a and IFN-y on influenza and ARI can greatly improve the prophylactic and therapeutic efficacy.

About the authors

Vladimir Vladimirovich Nikiforov

N.I. Pirogov Russian National Research Medical University

доктор мед. наук, проф., зав. каф. инфекционных болезней и эпидемиологии 1, Ostrovityanova Str., Moscow, Russian Federation, 117997

T. V Sologub

Research Institute of Influenza

Email: tomarasologub@rambler.ru
доктор мед. наук, проф., заместитель директора по научной и клинической работе 15/17, Professora Popova Str., Saint-Petersburg, Russian Federation, 197376

I. I Tokin

Research Institute of Influenza; North-Western State Medical University named after I.I. Mechnikov

Email: ivan.i.tokin@rambler.ru
канд. мед. наук, зав. отделением экспериментальной терапии вирусных гепатитов ФГБУ «НИИ гриппа» Минздрава России, доцент кафедры инфекционных болезней ГБОУ ВПО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России 15/17, Professora Popova Str., Saint-Petersburg, Russian Federation, 197376

V. V Tsvetkov

Research Institute of Influenza

Email: suppcolor@gmail.com
аспирант, науч. сотр. 15/17, Professora Popova Str., Saint-Petersburg, Russian Federation, 197376

M. K Erofeeva

Research Institute of Influenza

Email: mariana.erofeeva@influenza.spb.ru
доктор мед. наук, руководитель лаб. испытания новых средств защиты от вирусных инфекций 15/17, Professora Popova Str., Saint-Petersburg, Russian Federation, 197376

V. V Zarubaev

Research Institute of Influenza

Email: vladimir.zarubaev@influenza.spb.ru
канд. биол. наук, ст. науч. сотр. 15/17, Professora Popova Str., Saint-Petersburg, Russian Federation, 197376

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