The role of Helicobacter pylori in the process of 43 carcinogenesis by means of dysregulation of miRNA expression


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Abstract

Duodenal ulcer is associated with Helicobacter pylori almost in 90-100% of cases. Severe disease of the stomach - adenocarcinoma - is caused by infection with Helicobacter pylori in 70-90% of cases. Persons infected with this bacterium were proven statistically to be in group of the increased risk of the development of gastric cancer. Helicobacter pylori expresses a spectrum of virulence factors which cause dysregulation of intracellular signaling pathways in a host cell, that reduces the resistance to neoplastic transformation. In the review there are presented data about identified to the present time deregulated miRNAs associated with H.pylori diseases, including cancer of the stomach, and a few data on their biological significance. The growing number of studies confirming the involvement of miRNAs in various stages of carcinogenesis - from gastritis to the formation of metastases - demonstrates the importance of the new directions of the research.

About the authors

O. F Belaia

I.M. Sechenov First Moscow State Medical University

Email: ofbelaya@mail.ru
доктор мед. наук, проф., зав. лаб. по изучению токсических и септических состояний НИИ молекулярной медицины 8-2, Trubetskaya Str., Moscow, Russian Federation, 119991

E. V Volchkova

I.M. Sechenov First Moscow State Medical University

доктор мед. наук, проф., зав. каф. инфекционных болезней 8-2, Trubetskaya Str., Moscow, Russian Federation, 119991

O. A Paevskaya

I.M. Sechenov First Moscow State Medical University

канд. мед. наук, ст. науч. сотр. лаб. по изучению токсических и септических состояний НИИ молекулярной медицины 8-2, Trubetskaya Str., Moscow, Russian Federation, 119991

S. N Zuevskaya

I.M. Sechenov First Moscow State Medical University

канд. мед. наук, ст. науч. сотр. лаб. по изучению токсических и септических состояний НИИ молекулярной медицины 8-2, Trubetskaya Str., Moscow, Russian Federation, 119991

Yu. V Yudina

I.M. Sechenov First Moscow State Medical University

канд. мед. наук, ст. науч. сотр. лаб. по изучению токсических и септических состояний НИИ молекулярной медицины 8-2, Trubetskaya Str., Moscow, Russian Federation, 119991

S. G Pak

I.M. Sechenov First Moscow State Medical University

достор мед. наук, проф., член-корр. РАН, почетный зав. каф. инфекционных болезней 8-2, Trubetskaya Str., Moscow, Russian Federation, 119991

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