RISK FACTORS FOR THE DEVELOPMENT OF NON-HODGKIN’S LYMPHOMA IN PATIENTS WITH HIV AND HEPATITIS С COINFECTION


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Abstract

The objective of the study was to investigate risk factors for the development of non-Hodgkin's lymphoma (NHL) in HIV-infected patients with hepatitis С virus (HCV) coinfection. A total of 37 HIV-positive subjects with NHL treated in the Moscow Center for Prevention and Control of AIDS between 2009 and 2013 were included in the study. HIV patients were divided into 2 groups: 23 cases with HCV coinfection and 14 patients without HCV coinfection. At the time of making the diagnosis of NHL 90% of patients had CD4 cell count < 350 cell/mm 3. The mean CD4 cell count in the first group (120±123 cell/mm 3) was significantly lower (p=0,035), than in patients without HCV coinfection (267±253 cell/mm3). At the time of making the diagnosis of NHL 70% of patients had HIV viral load ≥5,00 log10. The mean viral load was 5,47±1,09 log10 copies/ml in the first group and 4,06±2,03 log10 copies/ml in the second group (p=0,033). At the time of making the diagnosis of NHL 78% of patients did not receive combination antiretroviral therapy (cART). In most patients who received cART virologic suppression unsufficient and CD4 cell count remained to be low. Risk factors associated with an increased risk of NHL in HIV-infected patients with HCV coinfection are low CD4 cell count, high HIV viral load and lack of effective cART. Timely initiation of cART followed by complete virologic suppression and CD4 recovery are key factors to prevent NHL in HIV-infected patients.

About the authors

E. L Melnikova

Moscow Centerfor Prevention and Control of AIDS

Email: eme1612@gmail.com
врач-инфекционист стационарного отд-ния ВИЧ-инфекции для взрослых 15, building 5, 8-th Sokolinoy Gory Street, Moscow, Russian Federation, 105275

E. V Volchkova

I. M. Sechenov First Moscow State Medical University

доктор мед. наук, проф., зав. каф. инфекционных болезней 8, building 2, Trubetskaya Str., Moscow, Russian Federation, 119991

E. V Ivannikov

Moscow Centerfor Prevention and Control of AIDS

зав. стационарным отд-нием ВИЧ-инфекции для взрослых 15, building 5, 8-th Sokolinoy Gory Street, Moscow, Russian Federation, 105275

A. Ya Olshansky

Moscow Centerfor Prevention and Control of AIDS

кандидат мед. наук, зав. лаб. отд-нием 15, building 5, 8-th Sokolinoy Gory Street, Moscow, Russian Federation, 105275

V. N Vdovina

Moscow Centerfor Prevention and Control of AIDS

врач-лаборант лабораторного отд-ния 15, building 5, 8-th Sokolinoy Gory Street, Moscow, Russian Federation, 105275

Yu. G Parkhomenko

Clinical Infectious Diseases Hospital №2

доктор мед. наук, проф., зав. патолого-анатомическим отд-нием 15, 8-th Sokolinoy Gory Str., Moscow

References

  1. Dal Maso L., Franceschi S. Epidemiology of non-Hodgkin lymphomas and other haemolymphopoietic neoplasms in people with AIDS. Lancet Oncol. 2003; 4 (2): 110-9.
  2. Soriano V., Vispo E., Labarga P., Medrano J., Barreiro P. Viral hepatitis and HIV co-infection. Antiviral Res. 2010; 85 (1): 303-15.
  3. Пивник А.В., Пархоменко Ю.Г., Криволапов Ю.А., Тишкевич О.А., Коровушкин В.Г., Ковригина А.М. и др. Соматические проблемы ВИЧ-медицины: СПИД-ассоциированные лимфомы. Онкогематология. 2007; 3: 27-37.
  4. Castillo J., Pantanowitz L., Dezube B.J. HIV-associated plasmablastic lymphoma: lessons learned from 112 published cases. Am. J. Hematol. 2008; 83 (10): 804-9.
  5. Rojas H.C., Merino M.C., Ghiringhelli M.J.P., Rodriguez A.J.R., Martinez L.E., Jensen R.W. Lymphomas associated with human immunodeficiency virus infection: retrospective review of medical records. Rev. Med. Chil. 2011; 139 (1): 27-35.
  6. Bower M., Fisher M., Hill T., Reeves I., Walsh J., Orkin C. et al. CD4 counts and the risk of systemic non-Hodgkin’s lymphoma in individuals with HIV in the UK. Haematologica. 2009; 94 (6): 875-80.
  7. Engels E.A., Pfeiffer R.M., Landgren O., Moore R.D. Immunologic and virologic predictors of AIDS-related non-Hodgkin lymphoma in the HAART era. J. Acquir Immune Defic. Syndr. 2010; 54 (1): 78-84.
  8. Silverberg M.J., Chao Ch., Leyden W.A., Xu L., Horberg M.A., Klein D. et al. HIV infection, Immunodeficiency, Viral Replication and the Risk of Cancer. Cancer Epidemiol. Biomarkers Prev. 2011; 20 (12): 2551-9.
  9. Guiguet M., Boué F., Cadranel J., Lang J.M., Rosenthal E., Costagliola D. et al. Effect of immunodeficiency, HIV viral load, and antiretroviral therapy on the risk of individual malignancies (FHDH-ANRS CO4): a prospective cohort study. Lancet Oncol. 2009; 10 (12): 1152-9.
  10. Collaboration of Observational HIV Epidemiological Research Europe (COHERE) Study Group, Bohlius J., Schmidlin K., Costagliola D., Fätkenheuer G., May M. et al. Incidence and risk factors of HIV-related non-Hodgkin’s lymphoma in the era of combination antiretroviral therapy: a European multicohort study. Antivir. Ther. 2009; 14 (8): 1065-74.
  11. When To Start Consortium. Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies. Lancet. 2009; 373 (9672): 1352-63.
  12. writing Committee for the CASCADE Collaboration. Timing of HAART initiation and clinical outcomes in human immunodeficiency virus type 1 seroconverters. Arch. Intern. Med. 2011; 171 (17): 1560-9.
  13. Zoufaly A., Stellbrink H.J., Heiden M.A., Kollan C., Hoffmann C., van Lunzen J. et al. Cumulative HIV viremia during highly active antiretroviral therapy is a strong predictor of AIDS-related lymphoma. J. Infect. Dis. 2009; 200 (1): 79-87.
  14. Raboud J., Anema A., Su D., Klein M.B., Zakaryan A., Swan T. et al. Relationship of chronic hepatitis C infection to rates of AIDS-defining illnesses in a Canadian cohort of HIV seropositive individuals receiving highly active antiretroviral therapy. HIV Clin. Trials. 2012; 13 (2): 90-102.
  15. Jaffe H.W., De Stavola B.L., Carpenter L.M., Porter K., Cox D.R. CASCADE Collaboration. Immune reconstitution and risk of Kaposi sarcoma and non-Hodgkin lymphoma in HIV-infected adults. AIDS. 2011; 25 (11): 1395-403.

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