ON THE QUESTION OF THE PATHOGENESIS OF HIV-INFECTION: THE ROLE OF IMMUNE ACTIVATION IN PROGRESSION OF DISEASE


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Abstract

Hyperactivaion of immme system is considered by most investigators as importantfactor, contributing to progression of HIV-infection and development ofAIDS. In the review modern knowledge about mechanisms and results of activation of immune system during HIV-infection are presented. HIV itself, opportunistic pathogens and components of gut microbiota, first of all, endotoxins ofgram-negative bacteria are considered as probable "activators" of immune system. High levels of endotoxin and markers of immune activation are associated with an even greater rate of progression of HIV-infection.

About the authors

G. R. Khasanova

State educational institution of Higher Professional Education “Kazan State Medical University”; Republic Centre for Prevention and Control of AIDS andInfectious Diseases, Mmistry of Public Health of the Republic of Tatarstan

Email: gulshatra@mail.ru
канд. мед. наук, доцент каф. детских инфекций Казанского государственного медицинского университета

I. G. Mustafin

State educational institution of Higher Professional Education “Kazan State Medical University”

доктор мед. наук, проф., зав. каф. биохимии Казанского государственного медицинского университета

V. A. Anokhin

State educational institution of Higher Professional Education “Kazan State Medical University”

доктор мед. наук, проф., зав. каф. детских инфекций Казанского государственного медицинского университета

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