Live influenza vaccine for children and adults: transmissibility in in vivo experiments

Irina Anatol'evna Dubrovina; Дубровина Ирина Анатольевна; Ekaterina Andreevna Bazhenova; Баженова Екатерина Андреевна; Irina Vasil'evna Kiseleva; Киселева Ирина Васильевна; Zh A Berdygulova; Бердыгулова Ж А; Natal'ya Valentinovna Larionova; Ларионова Наталья Валентиновна; Larisa Georgievna Rudenko; Руденко Лариса Георгиевна; I A Dubrovina; Dubrovina I A; E A Bazhenova; Bazhenova E A; I V Kiseleva; Kiseleva I V; Zh A Berdygulova; Berdygulova Zh A; N V Larionova; Larionova N V; L G Rudenko; Rudenko L G

doi:10.17816/EID40619

Live influenza vaccine for children and adults: transmissibility in in vivo experiments

Authors: Dubrovina I.A.¹, Bazhenova E.A.¹, Kiseleva I.V.¹, Berdygulova Z.A¹, Larionova N.V.¹, Rudenko L.G.¹, Dubrovina IA², Bazhenova EA², Kiseleva IV², Berdygulova Z.A², Larionova NV², Rudenko LG²
Affiliations:
1. НИИ экспериментальной медицины СЗО РАМН
2. Research Institute of Experimental Medicine, North-Western Branch, Russian Academy of Medical Sciences
Issue: Vol 16, No 6 (2011)
Pages: 14-18
Section: Articles
URL: https://journals.rcsi.science/1560-9529/article/view/40619
DOI: https://doi.org/10.17816/EID40619
ID: 40619

Cite item

Abstract

erson-to-person transmission plays a key role in the spread of seasonal and pandemic strains. To unveil the mechanisms underlying the transmissibility will be able to more effectively control influenza and search for new ways and methods of its prevention. Today vaccination is the most effective method for influenza prophylaxis. Therefore whether live influenza vaccine strains can spread in the population through their further reassortment with circulating viruses is extremely important. This investigation on a model of guinea pigs has studied whether wild-type and cold-adapted influenza viruses can be transmitted to uninfected animals. Influenza H5N1 virus is shown to be a highly transmissible agent to not only contact animals, but also to those which are a considerable distance from them. There is evidence that there is interference of cold-adapted strains with wild-type viruses, which opens new prospects for the use of live influenza vaccine in the pandemic situation and confirms that it is groundless to fear (be concerned) about that mass vaccination of population with live attenuated influenza vaccine may lead to the generation of reassortant mutant viruses with higher pathogenicity level.

Keywords

transmission, influenza virus, live attenuated influenza vaccine

References

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Live influenza vaccine for children and adults: transmissibility in in vivo experiments

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