Age-related clinical and epidemiological features of meningococcal infection in children and ways of improving therapy

Natal'ya Viktorovna Skripchenko; Скрипченко Наталья Викторовна; Yu V Lobzin; Лобзин Ю В; L A Alekseeva; Алексеева Л А; M V Ivanova; Иванова М В; A A Vil'nits; Вильниц А А; V V Karasev; Карасев В В; G P Ivanova; Иванова Г П; E Yu Gorelik; Горелик Е Ю; N F Pul'man; Пульман Н Ф; A S Kvetnaya; Кветная А С; M O Volkova; Волкова М О; K O Shevchenko; Шевченко К О; N V Skripchenko; Skripchenko N V; Yu V Lobzin; Lobzin Yu V; L A Alekseyeva; Alekseyeva L A; M V Ivanova; Ivanova M V; A A Vilnits; Vilnits A A; V V Karasev; Karasev V V; G P Ivanova; Ivanova G P; Ye Yu Gorelik; Gorelik Ye Yu; N F Pulman; Pulman N F; A S Kvetnaya; Kvetnaya A S; M O Volkova; Volkova M O; K O Shevchenko; Shevchenko K O

doi:10.17816/EID40448

Age-related clinical and epidemiological features of meningococcal infection in children and ways of improving therapy

Authors: Skripchenko N.V.¹, Lobzin Y.V¹, Alekseeva LA¹, Ivanova MV¹, Vil'nits AA¹, Karasev VV¹, Ivanova GP¹, Gorelik EY.¹, Pul'man NF¹, Kvetnaya AS¹, Volkova MO¹, Shevchenko KO¹, Skripchenko NV², Lobzin Y.V², Alekseyeva LA², Ivanova MV², Vilnits AA², Karasev VV², Ivanova GP², Gorelik Y.Y.², Pulman NF², Kvetnaya AS², Volkova MO², Shevchenko KO²
Affiliations:
1. ФГУ НИИ детских инфекций Федерального медико-биологического агентства
2. Research Institute of Childhood Infections, Federal Biomedical Agency
Issue: Vol 15, No 1 (2010)
Pages: 35-40
Section: Articles
URL: https://journals.rcsi.science/1560-9529/article/view/40448
DOI: https://doi.org/10.17816/EID40448
ID: 40448

Cite item

Abstract

The paper presents a clinical and laboratory analysis of generalized forms of meningococcal infection (MI) in 90 patients aged 1 month to 18 years. The age-related features of the disease under the present conditions and a relationship of its clinical manifestations to the serogroup of a meningococcus are determined. The implication of endogenous intoxication, proteolysis and a systemic inflammatory reaction in the pathogenesis of MI is established. The expediency of co-administration of antibacterial drugs and systemic enzymes and prolonged infusion therapy for generalized forms of MI is scientifically founded and the efficiency of the proposed therapeutic tactics is proven.

Keywords

children, meningococcal infection, meningitides, endogenous toxins, C-reactive protein, proteolysis, systemic enzymes

References

Алексеева Л. А. Значение белков и пептидов цереброспинальной жидкости в клинической лабораторной диагностике и патогенезе нейроинфекционных заболеваний у детей: Автореф. дис. ... д-ра биол. наук. - СПб., 2003.
Ветров В. В. // Эфферент. тер. - 2001. - Т. 7, № 1. - С. 4-7.
Дмитриев В. А., Ощепкова Е. В., Титов В. Н. // Тер. арх. - 2006. - № 5. - С. 86-89.
Зорин Н. А., Архипова С. В., Зорина В. Н. // Клин. мед. - 2006. - № 1. - С. 17-21.
Литвицкий П. Ф. // Вопр. соврем. педиатр. - 2006. - Т. 5, № 4. - С. 75-81.
Скрипченко Н. В. и др. // Педиатрия. - 2007. - № 1. - С. 101-115.
Сорокина М. Н., Иванова В. В., Скрипченко Н. В. Бактериальные гнойные менингиты у детей. - М., 2003.
Таболин В. А. и др. // Педиатрия. - 2001. - № 5. - С. 80-83.
Титов В. Н. // Клин. лаб. диагн. - 2004. - № 5. - С. 3-9.
Титов В. Н. // Клин. лаб. диагн. - 2008. - № 2. - С. 3- 14.

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Age-related clinical and epidemiological features of meningococcal infection in children and ways of improving therapy

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