Subacute brucellosis: A case report

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

Brucellosis is one of the most common zoonotic diseases worldwide. The epidemiological situation of brucellosis in the Russian Federation is characterized as unfavorable. Brucellosis remains a problem in regions with developed animal husbandry. The variety of clinical manifestations and the absence of specific symptoms of brucellosis make its diagnosis challenging. The clinical case presented in this paper illustrates the delayed diagnosis of brucellosis in a 10-year-old patient presenting with fever and enlarged lymph nodes, liver, and spleen. The failure in the provision of medical care was attributed to the lack of the alertness of doctors regarding brucellosis, insufficient interpretation of epidemiological history data, and incorrect assessment of the totality of the clinical syndrome of the disease and laboratory parameters. As a result, brucellosis was diagnosed only 6 months after disease onset. Subsequent etiotropic therapy led to the stabilization of the patient’s condition, who was discharged from the hospital with recommendations under the supervision of an infectious disease specialist.

About the authors

Murad Z. Shakhmardanov

Pirogov Russian National Research Medical University; Academy of Postgraduate Education

Author for correspondence.
Email: mur2025@rambler.ru
ORCID iD: 0000-0002-3168-2169
SPIN-code: 3312-4052

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow; Moscow

Vladimir V. Nikiforov

Pirogov Russian National Research Medical University; Academy of Postgraduate Education

Email: v.v.nikiforov@gmail.com
ORCID iD: 0000-0002-2205-9674
SPIN-code: 9044-5289

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow; Moscow

Nikita A. Tereshkin

Pirogov Russian National Research Medical University

Email: nteryoshkin@gmail.com
ORCID iD: 0009-0002-3541-4150
Russian Federation, Moscow

Shakhmardan E. Shakhmardanov

Dagestan State Medical University

Email: mshakhmardanov@yandex.ru
ORCID iD: 0009-0005-6723-1502
Russian Federation, Makhachkala

Anna A. Skryabina

Pirogov Russian National Research Medical University

Email: anna.skryabina.85@mail.ru
ORCID iD: 0000-0002-2098-222X
SPIN-code: 3692-6818

MD

Russian Federation, Moscow

Yuri N. Tomilin

Pirogov Russian National Research Medical University

Email: papa220471@mail.ru
ORCID iD: 0000-0003-2767-4868
SPIN-code: 8938-2621

MD, Cand. Sci. (Med.)

Russian Federation, Moscow

References

  1. Khoshnood S, Pakzad R, Koupaei M, et al. Prevalence, diagnosis, and manifestations of brucellosis: A systematic review and meta-analysis. Front Vet Sci. 2022;9:976215. doi: 10.3389/fvets.2022.976215
  2. Ponomarenko DG, Skudareva ON, Khachaturova AA, et al. Brucellosis: Trends in the Development of Situation in the World and Forecast for 2022 in the Russian Federation. Problemy Osobo Opasnykh Infektsii. 2022;2:36–45. (In Russ). doi: 10.21055/0370-1069-2022-2-36-45
  3. Chislo zaregistrirovannykh sluchaev infektsionnykh zabolevanii [Internet]. Edinaya mezhvedomstvennaya informatsionno-statisticheskaya sistema [cited 2023 Mar 22]. Available from: https://www.fedstat.ru/indicator/38208?ysclid.
  4. Shakhmardanov MZ, Abusueva AS, Nikiforov VV, et al. Incidence of brucellosis in the Republic of Dagestan in 2019. Epidemiology and Infectious Diseases. 2020;25(3):112−116. (In Russ). doi: 10.17816/EID50362
  5. Dzyuba GT, Skurikhina YE, Zakharova GA, Ponomareva AV. Brucellosis morbidity in Russia and Primorsky region. Pacific Medical Journal. 2021;4:50–55. (In Russ). doi: 10.34215/1609-1175-2021-4-50-55
  6. Mirijello A, Ritrovato N, D’Agruma A, et al. Abdominal Lymphadenopathies: Lymphoma, Brucellosis or Tuberculosis? Multidisciplinary Approach-Case Report and Review of the Literature. Medicina (Kaunas). 2023;59(2):293. doi: 10.3390/medicina59020293
  7. Sharif A, Heravi MM, Barahimi E, et al. Brucellosis presenting with sepsis and cholestasis: A rare presentation of an endemic disease with review of the literature. IDCases. 2022;29:e01519. doi: 10.1016/j.idcr.2022.e01519
  8. Doya LJ, Haidar I, Sakkour S. The association between acute brucellosis with a Guillain-Barré syndrome-like presentation: a case report. J Med Case Rep. 2023;17(1):25. doi: 10.1186/s13256-022-03740-w
  9. Yildirim AA, Kurt C, Çetinkol Y. Brucellosis with rare complications and review of diagnostic tests: a case report. J Med Case Rep. 2022;16(1):492. doi: 10.1186/s13256-022-03702-2
  10. Kulakov YuK, Dalgatova AA, Burgasova OA, Bacalin VV. Particular qualities of laboratory approaches in complex diagnosis of human brucellosis. Epidemiology and Infectious Diseases. 2021;26(4): 141–154. (In Russ). doi: 10.17816/EID108212
  11. Kurmanov B, Zincke D, Su W, et al. Assays for Identification and Differentiation of Brucella Species: A Review. Microorganisms. 2022;10(8):1584. doi: 10.3390/microorganisms10081584
  12. Kydyshov K, Usenbaev N, Sharshenbekov A, et al. Brucellosis in Humans and Animals in Kyrgyzstan. Microorganisms. 2022; 10(7):1293. doi: 10.3390/microorganisms10071293

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2023 Eco-Vector

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies