Synthesis and Anticholinesterase Activity of [(4 Z )-2-Aryl-4-(arylmethylidene)-5-oxo-4,5-dihydro-1 H -imidazol-1-yl]alkanoic Acids

V. O. Topuzyan; V. M. Kazoyan; R. A. Tamazyan; A. G. Aivazyan; L. Kh. Galstyan

doi:10.1134/S1070428018090178

Synthesis and Anticholinesterase Activity of [(4Z)-2-Aryl-4-(arylmethylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl]alkanoic Acids

作者: Topuzyan V.O.¹, Kazoyan V.M.¹, Tamazyan R.A.¹, Aivazyan A.G.¹, Galstyan L.K.²
隶属关系:
1. Scientific Technological Center of Organic and Pharmaceutical Chemistry
2. Yerevan State University
期: 卷 54, 编号 9 (2018)
页面: 1369-1377
栏目: Article
URL: https://journals.rcsi.science/1070-4280/article/view/218949
DOI: https://doi.org/10.1134/S1070428018090178
ID: 218949

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ω-[(4Z)-2-Aryl-4-arylmethylidene-5-oxo-4,5-dihydro-1H-imidazol-1-yl]alkanoic acids were synthesized by reaction of N-substituted α,β-dehydropeptides with chloro(trimethyl)silane or 1,1,1,3,3,3-hexamethyldisilazane. Both initial peptides and (4H)-imidazol-5-one derivatives based thereon were tested for anticholinesterase activity.