3,28-Bis-O-polyfluorobenzoylbetulin. Synthesis, Molecular Structure, and Cytotoxicity


Дәйексөз келтіру

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Аннотация

Treatment of betulin with 2,3,4,5-tetrafluoro- and pentafluorobenzoyl chlorides in triethylamine afforded 3,28-bis-O-polyfluorobenzoylbetulins. According to the X-ray diffraction data, all six-membered rings in the 3,28-bis-O-pentafluorobenzoylbetulin molecule appear in a chair conformation, and the five-membered ring has an envelope conformation with the C17 atom deviating from the plane formed by the other four carbon atoms. Unlike betulin itself, the obtained bis-esters showed no cytotoxic effect on human lung adenocarcinoma cell line A549 and human glioblastoma cell line U251.

Авторлар туралы

Yu. Trishin

Higher School of Technology and Energy

Хат алмасуға жауапты Автор.
Email: trish@YT4470.spb.edu
Ресей, ul. Ivana Chernykh 4, St. Petersburg, 198095

A. Fedorov

Higher School of Technology and Energy

Email: trish@YT4470.spb.edu
Ресей, ul. Ivana Chernykh 4, St. Petersburg, 198095

K. Lyssenko

Nesmeyanov Institute of Organoelement Compounds

Email: trish@YT4470.spb.edu
Ресей, ul. Vavilova 28, Moscow, 119991

D. Prokof’eva

Institute of Experimental Pharmacology

Email: trish@YT4470.spb.edu
Ресей, Kuz’molovskii, Leningrad oblast, 188663

Yu. Rudenok

Higher School of Technology and Energy

Email: trish@YT4470.spb.edu
Ресей, ul. Ivana Chernykh 4, St. Petersburg, 198095

V. Pavlova

Higher School of Technology and Energy

Email: trish@YT4470.spb.edu
Ресей, ul. Ivana Chernykh 4, St. Petersburg, 198095

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