3,28-Bis-O-polyfluorobenzoylbetulin. Synthesis, Molecular Structure, and Cytotoxicity
- Авторлар: Trishin Y.G.1, Fedorov A.N.1, Lyssenko K.A.2, Prokof’eva D.S.3, Rudenok Y.S.1, Pavlova V.V.1
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Мекемелер:
- Higher School of Technology and Energy
- Nesmeyanov Institute of Organoelement Compounds
- Institute of Experimental Pharmacology
- Шығарылым: Том 54, № 10 (2018)
- Беттер: 1480-1485
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-4280/article/view/219190
- DOI: https://doi.org/10.1134/S107042801810007X
- ID: 219190
Дәйексөз келтіру
Аннотация
Treatment of betulin with 2,3,4,5-tetrafluoro- and pentafluorobenzoyl chlorides in triethylamine afforded 3,28-bis-O-polyfluorobenzoylbetulins. According to the X-ray diffraction data, all six-membered rings in the 3,28-bis-O-pentafluorobenzoylbetulin molecule appear in a chair conformation, and the five-membered ring has an envelope conformation with the C17 atom deviating from the plane formed by the other four carbon atoms. Unlike betulin itself, the obtained bis-esters showed no cytotoxic effect on human lung adenocarcinoma cell line A549 and human glioblastoma cell line U251.
Авторлар туралы
Yu. Trishin
Higher School of Technology and Energy
Хат алмасуға жауапты Автор.
Email: trish@YT4470.spb.edu
Ресей, ul. Ivana Chernykh 4, St. Petersburg, 198095
A. Fedorov
Higher School of Technology and Energy
Email: trish@YT4470.spb.edu
Ресей, ul. Ivana Chernykh 4, St. Petersburg, 198095
K. Lyssenko
Nesmeyanov Institute of Organoelement Compounds
Email: trish@YT4470.spb.edu
Ресей, ul. Vavilova 28, Moscow, 119991
D. Prokof’eva
Institute of Experimental Pharmacology
Email: trish@YT4470.spb.edu
Ресей, Kuz’molovskii, Leningrad oblast, 188663
Yu. Rudenok
Higher School of Technology and Energy
Email: trish@YT4470.spb.edu
Ресей, ul. Ivana Chernykh 4, St. Petersburg, 198095
V. Pavlova
Higher School of Technology and Energy
Email: trish@YT4470.spb.edu
Ресей, ul. Ivana Chernykh 4, St. Petersburg, 198095
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