N -substituted 2-(6-amino-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-oxoacetamides

S. P. Gasparyan; M. V. Alexanyan; G. K. Arutyunyan; A. H. Martirosyan; R. V. Paronikyan; H. M. Stepanyan

doi:10.1134/S1070428016080145

N-substituted 2-(6-amino-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-oxoacetamides

Autores: Gasparyan S.P.¹, Alexanyan M.V.¹, Arutyunyan G.K.¹, Martirosyan A.H.¹, Paronikyan R.V.¹, Stepanyan H.M.¹
Afiliações:
1. R&D Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenian Republic
Edição: Volume 52, Nº 8 (2016)
Páginas: 1179-1182
Seção: Article
URL: https://journals.rcsi.science/1070-4280/article/view/214843
DOI: https://doi.org/10.1134/S1070428016080145
ID: 214843

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Resumo

In reaction of 6-aminouracyles with ethyl oxochloroacetate ethyl 2-(6-amino-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-oxoacetates were obtained, which by further reaction with various amines afforded oxo(pyrimidinyl)acetamides. According to the data of biological tests, the synthesized compounds showed low antibacterial and antitumor activity.