Synthesis of New Guanidine-Containing Amphiphiles and Their Pyrene Analog for Liposomal Delivery Systems and Visualization in Target Cells

A. A. Loseva; U. A. Budanova; Yu. L. Sebyakin

doi:10.1134/S1070428019120030

Synthesis of New Guanidine-Containing Amphiphiles and Their Pyrene Analog for Liposomal Delivery Systems and Visualization in Target Cells

Authors: Loseva A.A.¹, Budanova U.A.¹, Sebyakin Y.L.¹
Affiliations:
1. Lomonosov Moscow Institute of Fine Chemical Technology
Issue: Vol 55, No 12 (2019)
Pages: 1826-1831
Section: Article
URL: https://journals.rcsi.science/1070-4280/article/view/221441
DOI: https://doi.org/10.1134/S1070428019120030
ID: 221441

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Abstract

New cationic amphiphiles with a guanidine head group have been synthesized starting from lipoamino acids with the goal of creating drug and genetic material delivery systems. Their analog containing a pyrene fragment has also been obtained as a potential agent for visualization of liposome transport in various cells.