Synthesis of Spiro[benzo[h]chromene-4,3′-indoles] and Spiro[benzo[f]chromene-1,3′-indoles]


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New spiro heterocycles, spiro[benzo[h]chromene-4,3′-indoles] and spiro[benzo[f]chromene-1,3′-indoles], have been synthesized in 50–60% yield by three-component condensation of substituted isatins with malononitrile or ethyl cyanoacetate and naphthalen-1-ol or naphthalen-2-ol. The described reactions follow a cascade cyclization pathway and provide a regioselective method of synthesis of the title compounds.

Sobre autores

S. Poghosyan

Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry

Autor responsável pela correspondência
Email: safar.pogosyan@gmail.com
Armênia, Yerevan, 0014

M. Poghosyan

Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry

Email: safar.pogosyan@gmail.com
Armênia, Yerevan, 0014

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