Email this article Some Aspects of the Azide-Alkyne 1,3-Dipolar Cycloaddition Reaction
- Authors: Pokhodylo N.T.1, Tupychak M.A.1, Shyyka O.Y.1, Obushak M.D.1
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Affiliations:
- Ivan Franko National University of Lviv
- Issue: Vol 55, No 9 (2019)
- Pages: 1310-1321
- Section: Article
- URL: https://journals.rcsi.science/1070-4280/article/view/221149
- DOI: https://doi.org/10.1134/S1070428019090082
- ID: 221149
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Abstract
Some peculiar features of two most commonly used catalytic systems (Cul and CuSOVsodium ascorbate) controlling the regioselectivity of 1,3-dipolar cycloaddition of azides to terminal alkynes have been studied. Their potentialities, main disadvantages, and limitations have been demonstrated by a number of examples, including reactions of low-molecular-weight azides and alkynes containing heterocyclic substituents. The possibility of using novel reagents in click reactions is discussed.
About the authors
N. T. Pokhodylo
Ivan Franko National University of Lviv
Email: mykola.obushak@lnu.edu.ua
Ukraine, Lviv
M. A. Tupychak
Ivan Franko National University of Lviv
Email: mykola.obushak@lnu.edu.ua
Ukraine, Lviv
O. Ya. Shyyka
Ivan Franko National University of Lviv
Email: mykola.obushak@lnu.edu.ua
Ukraine, Lviv
M. D. Obushak
Ivan Franko National University of Lviv
Author for correspondence.
Email: mykola.obushak@lnu.edu.ua
Ukraine, Lviv
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