Chemical Properties of 6-Methyluracil-5-carbaldehyde Oxime


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Abstract

Oxidative chlorination of 6-methyluracil-5-carbaldehyde oxime in a two-phase system gave 7V-hydroxy-6-methyluracil-5-carboximidoyl chloride, and its bromination afforded ipso-substitution products, 5-bromo-6-methyluracil and 5,5-dibromo-6-hydroxy-6-methyl-5,6-dihydrouracil. The reaction of the title compound with acetic anhydride led to the formation of 6-methyluracil-5-carbonitrile or O-acetyl derivative, depending on the temperature. 7V-Hydroxy-6-methyluracyl-5-carboximidoyl chloride reacted with acetic acid at 100°C or with potassium iodide in boiling acetone to produce uracil-5-hydroxamic acid which was converted with high yields into the corresponding methyl ester and hydroximic acid amide. Quaternary ammonium salts were obtained by reactions of N-hydroxy-6-methyluracil-5-carboximidoyl chloride with pyridine and 1-methyl-1H-imidazole.

About the authors

I. B. Chernikova

Ufa Institute of Chemistry, Ufa Federal Research Center

Author for correspondence.
Email: inna.b.chernikova@yandex.ru
Russian Federation, Ufa, Bashkortostan

S. L. Khursan

Ufa Institute of Chemistry, Ufa Federal Research Center

Email: inna.b.chernikova@yandex.ru
Russian Federation, Ufa, Bashkortostan

L. V. Spirikhin

Ufa Institute of Chemistry, Ufa Federal Research Center

Email: inna.b.chernikova@yandex.ru
Russian Federation, Ufa, Bashkortostan

M. S. Yunusov

Ufa Institute of Chemistry, Ufa Federal Research Center

Email: inna.b.chernikova@yandex.ru
Russian Federation, Ufa, Bashkortostan

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