Email this article Synthesis of Bicyclic Isocyanates and Bioisosteric 1,3-Disubstituted Ureas as Soluble Epoxide Hydrolase Inhibitors
- Authors: Burmistrov V.V.1, D’yachenko V.S.1,2, Rasskazova E.V.2, Butov G.M.1
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Affiliations:
- Volzhsky Polytechnic Institute (Branch)
- Volgograd State Technical University
- Issue: Vol 55, No 8 (2019)
- Pages: 1166-1176
- Section: Article
- URL: https://journals.rcsi.science/1070-4280/article/view/221065
- DOI: https://doi.org/10.1134/S1070428019080165
- ID: 221065
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Abstract
(1S)-1-Isocyanato-4,7,7-trimethyl-2-oxabicyclo[2.2.1]heptan-3-one and 2-isocyanatobicyclo[2.2.1]-hept-5-ene were prepared by the Curtius rearragement reaction from the corresponding carboxylic acids. The synthesized isocyanates were used to synthesize, in high yields of 74–93%, bioisosteric 1,3-disubstituted ureas as potential human soluble epoxide hydrolase inhibitors.
About the authors
V. V. Burmistrov
Volzhsky Polytechnic Institute (Branch)
Email: butov@volpi.ru
Russian Federation, ul. Engel’sa 42a, Volzhskii, 404121
V. S. D’yachenko
Volzhsky Polytechnic Institute (Branch); Volgograd State Technical University
Email: butov@volpi.ru
Russian Federation, ul. Engel’sa 42a, Volzhskii, 404121; pr. Lenina 28, Volgograd, 400005
E. V. Rasskazova
Volgograd State Technical University
Email: butov@volpi.ru
Russian Federation, pr. Lenina 28, Volgograd, 400005
G. M. Butov
Volzhsky Polytechnic Institute (Branch)
Author for correspondence.
Email: butov@volpi.ru
Russian Federation, ul. Engel’sa 42a, Volzhskii, 404121
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