Email this article New Synthesis of Functionalized Nicotinamides
- Authors: Khrustalev V.N.1,2, Nenajdenko V.G.3, Dyachenko I.V.4, Kalashnik I.N.4, Dyachenko V.D.4, Dorovatovskii P.V.1
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Affiliations:
- “Kurchatov Institute” National Research Center
- Peoples’ Friendship University of Russia
- Faculty of Chemistry
- Taras Shevchenko Lugansk National University
- Issue: Vol 55, No 7 (2019)
- Pages: 1019-1033
- Section: Article
- URL: https://journals.rcsi.science/1070-4280/article/view/220948
- DOI: https://doi.org/10.1134/S1070428019070194
- ID: 220948
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Abstract
An efficient method has been developed for the synthesis of 6-(alkylsulfanyl)-4-aryl(hetaryl)-N-aryl-5-cyano-2-methylpyridine-3-carboxamides by condensation of aromatic or heteroaromatic aldehydes with cyanothioacetamide and acetoacetanilides in the presence of triethylamine or morpholine, followed by S-alkylation.
About the authors
V. N. Khrustalev
“Kurchatov Institute” National Research Center; Peoples’ Friendship University of Russia
Email: nenajdenko@gmail.com
Russian Federation, Moscow; Moscow
V. G. Nenajdenko
Faculty of Chemistry
Author for correspondence.
Email: nenajdenko@gmail.com
Russian Federation, Moscow
I. V. Dyachenko
Taras Shevchenko Lugansk National University
Email: nenajdenko@gmail.com
Ukraine, Lugansk
I. N. Kalashnik
Taras Shevchenko Lugansk National University
Email: nenajdenko@gmail.com
Ukraine, Lugansk
V. D. Dyachenko
Taras Shevchenko Lugansk National University
Email: nenajdenko@gmail.com
Ukraine, Lugansk
P. V. Dorovatovskii
“Kurchatov Institute” National Research Center
Email: nenajdenko@gmail.com
Russian Federation, Moscow
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