Alkylation of 5,5-Substituted N-[4-Methyl-3-phenylfuran-2(5H)-ylidene]-N′-phenylthioureas

详细

The alkylation of 5,5-disubstituted N-[4-methyl-3-phenylfuran-2(5H)-ylidene]-N′-phenylthioureas with ethyl chloroacetate in the presence of potassium carbonate at a ratio of 1:1:0.6 led to the formation of the corresponding S-(ethoxycarbonylmethyl) derivatives. The reaction with an equimolar amount of potassium carbonate involved intramolecular cyclization of the alkylation products to give spirocyclic compounds.