Synthesis of Purine and 2-Aminopurine Conjugates with N-(4-Aminobenzoyl)-(S)-glutamic Acid

Abstract

Purine and 2-aminopurine conjugates with N-(4-aminobenzoyl)-(S)-glutamic acid connected to C⁶ of the purine system either directly or through an aminoethyl linker have been synthesized by nucleophilic substitution of chlorine in 6-chloropurine and 2-amino-6-chloropurine. 2-Aminopurine conjugate with 4-aminobenzoic acid linked through a glycine residue has also been obtained. Testing of the synthesized compounds for tuberculostatic activity in vitro has revealed a moderate activity of methyl 4-[2-(2-aminopurin-6-ylamino)-acetyl]amino}benzoate.