Email this article 14β-(Isoxazol-3-yl)methylestrane Steroids: Chemoselective Synthesis and Transformations with Heterocyclic Ring Opening
- Authors: Baranovsky A.V.1, Ladyko A.S.1, Shatskaya V.A.2, Scherbakov A.M.2
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Affiliations:
- Institute of Bioorganic Chemistry
- Blokhin National Medical Research Center of Oncology
- Issue: Vol 55, No 2 (2019)
- Pages: 202-214
- Section: Article
- URL: https://journals.rcsi.science/1070-4280/article/view/219862
- DOI: https://doi.org/10.1134/S107042801902012X
- ID: 219862
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Abstract
Steroids containing an isoxazole, isoxazoline, or enaminocarbonyl substituent at C-14 and a C-14-C-15-fused pyrrolidine ring were synthesized. The influence of solvents on the result of dipolar cycloaddition and solvolysis of bridged nitrosteroids was evaluated. Cytotoxicity testing of estrone analogs on cancer cells of various origins revealed activity against breast, colorectal, prostate, and lung cancer cells.
About the authors
A. V. Baranovsky
Institute of Bioorganic Chemistry
Author for correspondence.
Email: baranovsky@iboch.by
Belarus, ul. Kuprevicha 5/2, Minsk, 220147
A. S. Ladyko
Institute of Bioorganic Chemistry
Email: alex.scherbakov@gmail.com
Belarus, ul. Kuprevicha 5/2, Minsk, 220147
V. A. Shatskaya
Blokhin National Medical Research Center of Oncology
Email: alex.scherbakov@gmail.com
Russian Federation, Kashirskoe shosse 24, Moscow, 115522
A. M. Scherbakov
Blokhin National Medical Research Center of Oncology
Author for correspondence.
Email: alex.scherbakov@gmail.com
Russian Federation, Kashirskoe shosse 24, Moscow, 115522
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