Synthesis of Polyfunctionalized Hexahydropyrimidines

A. G. Badamshin; D. R. Latypova; V. A. Dokichev

doi:10.1134/S1070428019020076

Synthesis of Polyfunctionalized Hexahydropyrimidines

Authors: Badamshin A.G.¹^,2, Latypova D.R.¹, Dokichev V.A.¹^,2
Affiliations:
1. Ufa Institute of Chemistry, Ufa Research Center
2. Ufa State Aviation Technical University
Issue: Vol 55, No 2 (2019)
Pages: 168-173
Section: Article
URL: https://journals.rcsi.science/1070-4280/article/view/219816
DOI: https://doi.org/10.1134/S1070428019020076
ID: 219816

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Abstract

The reactions of alkyl 5-acetylhexahydropyrimidine-5-carboxylates with ammonia, hydrazine hydrate, and lithium aluminum hydride were used to synthesize hexahydropyrimidine derivatives containing pharmacophoric 1,3-propylenediamine and 1,3-propanolamine fragments.

Keywords

synthesis, alkyl 5-acetylhexahydropyrimidine-5-carboxylates, ammonia, hydrazine hydrate, lithium aluminum hydride

About the authors

A. G. Badamshin

Ufa Institute of Chemistry, Ufa Research Center; Ufa State Aviation Technical University

Email: dokichev@anrb.ru
Russian Federation, pr. Oktyabrya 69, Ufa, 450054; ul. K. Marksa 12, Ufa, 450008

D. R. Latypova

Ufa Institute of Chemistry, Ufa Research Center

Email: dokichev@anrb.ru
Russian Federation, pr. Oktyabrya 69, Ufa, 450054

V. A. Dokichev

Ufa Institute of Chemistry, Ufa Research Center; Ufa State Aviation Technical University

Author for correspondence.
Email: dokichev@anrb.ru
Russian Federation, pr. Oktyabrya 69, Ufa, 450054; ul. K. Marksa 12, Ufa, 450008

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