Synthesis of (2S)-4-Methyl- and (2S)-4-Methyl-6-oxo-3,6-dihydro-2H-pyran-2-carbaldehydes as Precursors to C22–C27 Fragments of Fijianolides and Their Synthetic Analogs

Abstract

New schemes of synthesis of (2S)-4-methyl- and (2S)-4-methyl-6-oxo-3,6-dihydro-2H-pyran-2-carbaldehydes have been developed with the goal of obtaining C²²–C²⁷ fragments of fijianolides and their synthetic analogs on the basis of transformations of cyclopropanol intermediates. The C²²–C²⁷ block of fijianolides A and B has been synthesized.