Synthesis and Structure of New Substituted Pyrimidinone with Unsaturated Side Chain


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Abstract

Melting of a mixture of 5-substituted 2,4-dimethyl-1,6-dihydropyrimidin-6-ones with cinnamic aldehyde, 1-methylindoline-2,3-dione and 6-methoxy-2-chloroquinoline-3-carbaldehyde in the presence of ZnCl2 led to the formation of substituted pyrimidines with conjugated bonds in the position 2. The structure of synthesized compounds as 2-isomers was confirmed by 2D 1H NMR NOESY data.

About the authors

A. A. Harutyunyan

Russian–Armenian (Slavic) University; The Scientifical and Technological Centre of Organic and Pharmaceutical Chemistry

Author for correspondence.
Email: harutyunyan.arthur@yahoo.com
Armenia, Yerevan, 0051; Azatutyan pr. 26, Yerevan, 0014

G. T. Gukasyan

Russian–Armenian (Slavic) University

Email: harutyunyan.arthur@yahoo.com
Armenia, Yerevan, 0051

H. A. Panosyan

The Scientifical and Technological Centre of Organic and Pharmaceutical Chemistry

Email: harutyunyan.arthur@yahoo.com
Armenia, Azatutyan pr. 26, Yerevan, 0014

R. A. Tamazyan

The Scientifical and Technological Centre of Organic and Pharmaceutical Chemistry

Email: harutyunyan.arthur@yahoo.com
Armenia, Azatutyan pr. 26, Yerevan, 0014

A. G. Aivazyan

The Scientifical and Technological Centre of Organic and Pharmaceutical Chemistry

Email: harutyunyan.arthur@yahoo.com
Armenia, Azatutyan pr. 26, Yerevan, 0014

G. G. Danagulyan

Russian–Armenian (Slavic) University; The Scientifical and Technological Centre of Organic and Pharmaceutical Chemistry

Email: harutyunyan.arthur@yahoo.com
Armenia, Yerevan, 0051; Azatutyan pr. 26, Yerevan, 0014

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