Email this article Reductive Heterocyclization of 2-Cyanobenzophenones by the Action of NaBH4. New Efficient Synthesis of 3-Arylphthalides
- Authors: Mochalov S.S.1, Fedotov A.N.1, Trofimova E.V.1, Zefirov N.S.1
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Affiliations:
- Faculty of Chemistry
- Issue: Vol 54, No 4 (2018)
- Pages: 568-572
- Section: Review
- URL: https://journals.rcsi.science/1070-4280/article/view/217512
- DOI: https://doi.org/10.1134/S1070428018040085
- ID: 217512
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Abstract
The reduction of 2-cyclopropylcarbonyl-, 2-(thiophen-2-yl)carbonyl-, and 2-arylcarbonylbenzonitriles with sodium tetrahydridoborate afforded 3-cyclopropyl-, 3-(2-thiophen-2-yl)-, and 3-arylphthalides, respectively, in high yields. Under analogous conditions, 3-cyanobenzophenones were converted to the corresponding 3-cyanobenzhydrols.
About the authors
S. S. Mochalov
Faculty of Chemistry
Email: fed@org.chem.msu.ru
Russian Federation, Leninskie gory 1, Moscow, 119991
A. N. Fedotov
Faculty of Chemistry
Author for correspondence.
Email: fed@org.chem.msu.ru
Russian Federation, Leninskie gory 1, Moscow, 119991
E. V. Trofimova
Faculty of Chemistry
Email: fed@org.chem.msu.ru
Russian Federation, Leninskie gory 1, Moscow, 119991
N. S. Zefirov
Faculty of Chemistry
Email: fed@org.chem.msu.ru
Russian Federation, Leninskie gory 1, Moscow, 119991
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