Email this article Synthesis and Antimycobacterial Activity of Hydrazides Based on Pyridoxine Derivatives
- Authors: Khaziev R.M.1, Shtyrlin N.V.1, Lodochnikova O.A.2, Volobueva N.V.3, Chestnova R.V.3, Alekseev A.P.3, Romanova E.I.1, Balakin K.V.1,4, Shtyrlin Y.G.1
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Affiliations:
- Scientific Educational Center of Pharmaceutics
- Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
- Republican Clinical Antitubercular Dispensary
- Sechenov First Moscow State Medical University
- Issue: Vol 54, No 3 (2018)
- Pages: 426-430
- Section: Article
- URL: https://journals.rcsi.science/1070-4280/article/view/217304
- DOI: https://doi.org/10.1134/S1070428018030090
- ID: 217304
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Abstract
Pyridoxine derivatives, 3-hydroxy-2-methylpyridine-4- and -5-carbohydrazides, were synthesized according to optimized known procedures, and a method for the synthesis of 5-(hydroxymethyl)-2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine-6-carbohydrazide was developed. The hydroxymethyl groups in positions 5 and 6 of 2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine showed different reactivities, and only the 6-hydroxymethyl group was selectively oxidized to aldehyde under mild conditions. The lactone ring in 5,6-dihydrofuro[3,4-b]pyridin-7(5H)-one was found to be stable to nucleophiles. The synthesized hydrazides showed no antimycobacterial activity.
About the authors
R. M. Khaziev
Scientific Educational Center of Pharmaceutics
Email: Yurii.Shtyrlin@gmail.com
Russian Federation, ul. Kremlevskaya 18, Kazan, Tatarstan, 420008
N. V. Shtyrlin
Scientific Educational Center of Pharmaceutics
Email: Yurii.Shtyrlin@gmail.com
Russian Federation, ul. Kremlevskaya 18, Kazan, Tatarstan, 420008
O. A. Lodochnikova
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
Email: Yurii.Shtyrlin@gmail.com
Russian Federation, ul. Arbuzova 8, Kazan, Tatarstan, 420088
N. V. Volobueva
Republican Clinical Antitubercular Dispensary
Email: Yurii.Shtyrlin@gmail.com
Russian Federation, ul. Shalyapina 20, Kazan, Tatarstan, 420049
R. V. Chestnova
Republican Clinical Antitubercular Dispensary
Email: Yurii.Shtyrlin@gmail.com
Russian Federation, ul. Shalyapina 20, Kazan, Tatarstan, 420049
A. P. Alekseev
Republican Clinical Antitubercular Dispensary
Email: Yurii.Shtyrlin@gmail.com
Russian Federation, ul. Shalyapina 20, Kazan, Tatarstan, 420049
E. I. Romanova
Scientific Educational Center of Pharmaceutics
Email: Yurii.Shtyrlin@gmail.com
Russian Federation, ul. Kremlevskaya 18, Kazan, Tatarstan, 420008
K. V. Balakin
Scientific Educational Center of Pharmaceutics; Sechenov First Moscow State Medical University
Email: Yurii.Shtyrlin@gmail.com
Russian Federation, ul. Kremlevskaya 18, Kazan, Tatarstan, 420008; Bol’shaya Pirogovskaya ul. 2-4, Moscow, 119991
Yu. G. Shtyrlin
Scientific Educational Center of Pharmaceutics
Author for correspondence.
Email: Yurii.Shtyrlin@gmail.com
Russian Federation, ul. Kremlevskaya 18, Kazan, Tatarstan, 420008
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