Email this article Synthesis of Benzo[h]quinazolines from Ethyl 1-Amino-3-cyclohexyl-3,4-dihydronaphthalene-2-carboxylate
- Authors: Grigoryan N.P.1
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Affiliations:
- Mndzhoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry
- Issue: Vol 54, No 1 (2018)
- Pages: 55-61
- Section: Article
- URL: https://journals.rcsi.science/1070-4280/article/view/217130
- DOI: https://doi.org/10.1134/S1070428018010049
- ID: 217130
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Abstract
The reaction of ethyl (2Z)-2-cyano-3-cyclohexylprop-2-enoate with benzylmagnesium chloride, followed by cyclization in the presence of sulfuric acid, provided an efficient method of synthesis of ethyl 1-amino-3-cyclohexyl-3,4-dihydronaphthalene-2-carboxylate which was converted to a number of new heterocyclic systems containing a benzo[h]quinazoline fragment.
About the authors
N. P. Grigoryan
Mndzhoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry
Author for correspondence.
Email: nver-55@mail.ru
Armenia, pr. Azatutyan 26, Yerevan, 0014
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