Synthesis and anti-influenza activity of 2-cyanoethoxy and 2-(1 H -tetrazol-5-yl)ethoxy derivatives of dammarane-type triterpenoids

A. D. Zorina; A. S. Kaledina; I. A. Motsepuro; V. V. Anokhina; S. A. Marchenko; S. I. Selivanov; V. V. Zarubaev; R. E. Trifonov

doi:10.1134/S1070428017110185

Synthesis and anti-influenza activity of 2-cyanoethoxy and 2-(1H-tetrazol-5-yl)ethoxy derivatives of dammarane-type triterpenoids

Authors: Zorina A.D.¹, Kaledina A.S.¹, Motsepuro I.A.¹, Anokhina V.V.¹, Marchenko S.A.¹, Selivanov S.I.¹, Zarubaev V.V.², Trifonov R.E.¹
Affiliations:
1. St. Petersburg State University
2. St. Petersburg Pasteur Research Institute of Epidemiology and Microbiology
Issue: Vol 53, No 11 (2017)
Pages: 1710-1716
Section: Article
URL: https://journals.rcsi.science/1070-4280/article/view/216962
DOI: https://doi.org/10.1134/S1070428017110185
ID: 216962

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Abstract

A series of 3-(2-1Н-tetrazol-5-ylethoxy- and 2-1Н-tetrazol-5-ylethoxyimino) derivatives of dammarane triterpenoids was synthesized by azidation of 3-(2-cyanoethoxy- and 2-cyanoethoxyimino)-dammaranes. The anti-influenza activity of the prepared tetrazolyldammaranes and intermediate compounds against influenza virus А H1N1 was tested. A considerable antiviral activity was observed for 20(S)-3-(2-1Н-tetrazol-5-ylethoxyimino)-25,26,27-trinor-20,24-olidedammarane (SI 26).