Synthesis of new 1-(3,4-dimethylphenyl)-1,5-dihydropyrazolo[3,4-d]pyrimidin-4-one derivatives
- Authors: Zhidkov M.E.1, Kutkin A.V.1, Fetisova E.N.1, Zverev D.M.1, Zaraeva N.V.1, Gorokhov V.V.1, Chubarova O.V.1
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Affiliations:
- State Research Institute of Organic Chemistry and Technology
- Issue: Vol 53, No 4 (2017)
- Pages: 592-598
- Section: Review
- URL: https://journals.rcsi.science/1070-4280/article/view/216094
- DOI: https://doi.org/10.1134/S1070428017040157
- ID: 216094
Cite item
Abstract
New substituted pyrazolo[3,4-d]pyrimidin-4-ones have been synthesized as a result of a series of transformations including hydrolysis of ethyl 5-amino-1H-pyrazole-4-carboxylates, cyclization of the carboxylic acids thus obtained to pyrazolo[3,4-d][1,3]oxazin-4(1H)-ones, and treatment of the latter with substituted anilines. The final pyrazolo[3,4-d]pyrimidin-4-one derivatives can also be synthesized from 5-(arylamido)-1H-pyrazole-4-carboxylic acids in the presence of a catalytic amount of anhydrous zinc(II) chloride.
About the authors
M. E. Zhidkov
State Research Institute of Organic Chemistry and Technology
Email: dir@gosniiokht.ru
Russian Federation, sh. Entuziastov 23, Moscow, 111024
A. V. Kutkin
State Research Institute of Organic Chemistry and Technology
Email: dir@gosniiokht.ru
Russian Federation, sh. Entuziastov 23, Moscow, 111024
E. N. Fetisova
State Research Institute of Organic Chemistry and Technology
Author for correspondence.
Email: dir@gosniiokht.ru
Russian Federation, sh. Entuziastov 23, Moscow, 111024
D. M. Zverev
State Research Institute of Organic Chemistry and Technology
Email: dir@gosniiokht.ru
Russian Federation, sh. Entuziastov 23, Moscow, 111024
N. V. Zaraeva
State Research Institute of Organic Chemistry and Technology
Email: dir@gosniiokht.ru
Russian Federation, sh. Entuziastov 23, Moscow, 111024
V. V. Gorokhov
State Research Institute of Organic Chemistry and Technology
Email: dir@gosniiokht.ru
Russian Federation, sh. Entuziastov 23, Moscow, 111024
O. V. Chubarova
State Research Institute of Organic Chemistry and Technology
Email: dir@gosniiokht.ru
Russian Federation, sh. Entuziastov 23, Moscow, 111024
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