Cyclocondensations of 3-alkylpyrazol-5-amines with 3-arylprop-2-enals and cyclic 1,3-diketones


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Abstract

Domino reactions of 3-alkylpyrazol-5-amines with 3-arylprop-2-enals and cyclic 1,3-diketones regioselectively afforded pyrazolo[3,4-b]pyridine derivatives. The alkylation and acylation of the synthesized compounds were studied using 3,7,7-trimethyl-4-[(E)-2-phenylethenyl]-2,4,6,7,8,9-hexahydro-5H-pyrazolo-[3,4-b]quinolin-5-one as model.

About the authors

N. I. Zemlyanaya

Danilevskii Institute of Endocrinous Pathology Problems; Institute for Single Crystals

Email: lipson@ukr.net
Ukraine, ul. Alchevskikh 10, Kharkiv, 61002; pr. Lenina 60, Kharkiv, 61001

V. V. Borodina

Danilevskii Institute of Endocrinous Pathology Problems

Email: lipson@ukr.net
Ukraine, ul. Alchevskikh 10, Kharkiv, 61002

V. I. Musatov

Institute for Single Crystals

Email: lipson@ukr.net
Ukraine, pr. Lenina 60, Kharkiv, 61001

S. V. Shishkina

Institute for Single Crystals; Karazin Kharkiv National University

Email: lipson@ukr.net
Ukraine, pr. Lenina 60, Kharkiv, 61001; pl. Svobody 4, Kharkiv, 61022

D. S. Sofronov

Institute for Single Crystals

Email: lipson@ukr.net
Ukraine, pr. Lenina 60, Kharkiv, 61001

V. V. Lipson

Danilevskii Institute of Endocrinous Pathology Problems; Institute for Single Crystals; Karazin Kharkiv National University

Author for correspondence.
Email: lipson@ukr.net
Ukraine, ul. Alchevskikh 10, Kharkiv, 61002; pr. Lenina 60, Kharkiv, 61001; pl. Svobody 4, Kharkiv, 61022

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